Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | CNR1 | P21554 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.32 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | XDH | P47989 | 1/20 | 0.31 |
| ▸ | ALPL | P05186 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.30 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.30 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.30 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3263304 | 0.88 | IKBKB (0.41) | HPGDSMN1; SMN2LRRK2ALDH1A1TDP1 | |
| SCHEMBL3264021 | 0.85 | HPGD (0.40) | HPGDSMN1; SMN2LRRK2ALDH1A1TDP1 | |
| SCHEMBL3261776 | 0.70 | MAPK1 (0.50) | HPGDSMN1; SMN2LRRK2ALDH1A1KDM4E | |
| SCHEMBL3260006 | 0.67 | CHEK1 (0.56) | HPGDSMN1; SMN2LRRK2ALDH1A1KDM4E | |
| SCHEMBL3390203 | 0.67 | MAPK1 (0.43) | HPGDALDH1A1KDM4ETP53CNR1 | |
| SCHEMBL12398406 | 0.66 | NFKB1 (0.46) | HPGDSMN1; SMN2ALDH1A1TDP1KDM4E | |
| SCHEMBL470104 | 0.63 | NQO1 (0.64) | HPGDSMN1; SMN2ALDH1A1TDP1KDM4E | |
| SCHEMBL13495080 | 0.63 | L3MBTL1 (0.55) | LRRK2CNR1CNR2GPR55MEN1 | |
| SCHEMBL8094545 | 0.62 | POLB (0.36) | HPGDALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL3263505 | 0.62 | LRRK2 (0.40) | LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010015656-A2 | NEW ALKOXYPYRAZOLES | INSTITUT PASTEUR (FR) | 2010-02-11 | — | — | WO | disclosed |
| EP-2151434-A1 | Alkoxypyrazoles and the process for their preparation | Institut Pasteur (FR) | 2010-02-10 | — | — | EP | disclosed |