Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | THRB | P10828 | 3/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KIF11 | P52732 | 1/20 | 0.40 |
| ▸ | ALPL | P05186 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12543097 | 0.79 | KMT2A (0.55) | KMT2AHSD11B1MEN1CYP1A2CRHR1 | |
| SCHEMBL13499106 | 0.76 | LMNA (0.64) | THRBHSD11B1ALDH1A1LMNAHPGD | |
| SCHEMBL16144908 | 0.76 | KMT2A (0.35) | KMT2ATHRBMEN1ALPLCYP1A2 | |
| SCHEMBL20239533 | 0.75 | POLB (0.45) | KMT2AHSD11B1MEN1ALPLALDH1A1 | |
| SCHEMBL8823116 | 0.75 | HSD11B1 (0.54) | KMT2AHSD11B1MEN1 | |
| SCHEMBL949842 | 0.74 | ALDH1A1 (0.47) | KMT2AHSD11B1HIF1AALDH1A1 | |
| SCHEMBL461125 | 0.72 | KMT2A (0.47) | KMT2AHSD11B1MEN1ALDH1A1 | |
| SCHEMBL31673611 | 0.72 | KMT2A (0.47) | KMT2AHSD11B1MEN1ALDH1A1 | |
| SCHEMBL13738970 | 0.71 | HSD11B1 (0.49) | KMT2AHSD11B1MEN1ALPLCYP1A2 | |
| SCHEMBL1940302 | 0.71 | KMT2A (0.64) | KMT2AMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7659408-B2 | Pyrazole carboxamides as inhibitors of 11-β-hydroxysteroid dehydrogenase-1 | Merck Sharp & Dhome Corp. (US) | 2010-02-09 | — | — | US | disclosed |
| US-7659408-B2 | Pyrazole carboxamides as inhibitors of 11-β-hydroxysteroid dehydrogenase-1 | Merck Sharp & Dhome Corp. (US) | 2010-02-09 | — | — | US | disclosed |
| US-20080153893-A1 | Pyrazole Carboxamides as Inhibitors of 11-Beta-Hydroxysteroid Dehydrogenase-1 | MERCK SHARP & DOHME CORP. | 2008-06-26 | — | — | US | disclosed |
| US-20080153893-A1 | Pyrazole Carboxamides as Inhibitors of 11-Beta-Hydroxysteroid Dehydrogenase-1 | MERCK SHARP & DOHME CORP. | 2008-06-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080153893-A1 | Pyrazole Carboxamides as Inhibitors of 11-Beta-Hydroxysteroid Dehydrogenase-1 | HSD11B1, HSD17B1, HSD3B1 | KMT2A 2227/4885THRB 1258/4885HSD11B1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.