Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NQO2 | P16083 | 9/20 | 0.78 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | TOP1 | P11387 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | CASP1 | P29466 | 1/20 | 0.46 |
| ▸ | CASP7 | P55210 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | TOP2A | P11388 | 1/20 | 0.45 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.45 |
| ▸ | F2 | P00734 | 4/20 | 0.43 |
| ▸ | F10 | P00742 | 3/20 | 0.43 |
| ▸ | WDR5 | P61964 | 1/20 | 0.41 |
| ▸ | MASP2 | O00187 | 1/20 | 0.40 |
| ▸ | PLAU | P00749 | 1/20 | 0.40 |
| ▸ | THPO | P40225 | 1/20 | 0.40 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.39 |
| ▸ | APEX1 | P27695 | 1/20 | 0.39 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL549141 | 0.88 | NQO2 (1.00) | NQO2ALDH1A1TOP1HPGDCASP1 | |
| SCHEMBL13573621 | 0.81 | NQO2 (0.83) | NQO2ALDH1A1TOP1HPGDCASP1 | |
| SCHEMBL6750104 | 0.74 | NQO2 (0.72) | NQO2ALDH1A1TOP1HPGDCASP1 | |
| SCHEMBL19309697 | 0.69 | NQO2 (0.61) | NQO2ALDH1A1TOP1HPGDCASP1 | |
| SCHEMBL27639231 | 0.69 | NQO2 (0.64) | NQO2ALDH1A1TOP1HPGDCASP1 | |
| SCHEMBL15653057 | 0.67 | MASP2 (0.48) | ALDH1A1CASP1HSD17B10TDP1F2 | |
| SCHEMBL25914317 | 0.67 | CYP2D6 (0.55) | ALDH1A1HPGDPLAU | |
| SCHEMBL14339598 | 0.66 | GRIN2B (0.56) | HPGDHSD17B10TDP1WDR5 | |
| SCHEMBL394218 | 0.66 | WDR5 (0.80) | NQO2ALDH1A1TOP1HPGDCASP1 | |
| SCHEMBL8973288 | 0.66 | WDR5 (0.80) | NQO2ALDH1A1TOP1HPGDCASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090298934-A1 | Diamidine Inhibitors of TDP1 | GOVERNMENT OF THE US, AS REPRESENTED BY THE SECRET (US) | 2009-12-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090298934-A1 | Diamidine Inhibitors of TDP1 | TDP1, TDP2, DTD1 | NQO2 384/4885ALDH1A1 1259/4885TOP1 105/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.