Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NQO2 | P16083 | 9/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.49 |
| ▸ | PRMT1 | Q99873 | 2/20 | 0.49 |
| ▸ | TOP1 | P11387 | 1/20 | 0.49 |
| ▸ | CASP1 | P29466 | 1/20 | 0.49 |
| ▸ | CASP7 | P55210 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | TOP2A | P11388 | 1/20 | 0.47 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.47 |
| ▸ | WDR5 | P61964 | 1/20 | 0.43 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL549141 | 0.84 | NQO2 (1.00) | NQO2ALDH1A1HPGDHSD17B10PRMT1 | |
| SCHEMBL13573621 | 0.77 | NQO2 (0.83) | NQO2ALDH1A1HPGDHSD17B10PRMT1 | |
| SCHEMBL13575267 | 0.74 | NQO2 (0.78) | NQO2ALDH1A1HPGDHSD17B10PRMT1 | |
| SCHEMBL27639231 | 0.71 | NQO2 (0.64) | NQO2ALDH1A1HPGDHSD17B10PRMT1 | |
| SCHEMBL8973288 | 0.69 | WDR5 (0.80) | NQO2ALDH1A1HPGDHSD17B10PRMT1 | |
| SCHEMBL394218 | 0.69 | WDR5 (0.80) | NQO2ALDH1A1HPGDHSD17B10PRMT1 | |
| SCHEMBL12461484 | 0.68 | WDR5 (0.64) | NQO2ALDH1A1HPGDHSD17B10PRMT1 | |
| Furamidine SCHEMBL549198 | 0.66 | NQO2 (1.00) | NQO2ALDH1A1HPGDHSD17B10PRMT1 | |
| SCHEMBL537030 | 0.66 | LMNA (0.77) | NQO2ALDH1A1HPGDHSD17B10PRMT1 | |
| SCHEMBL4357250 | 0.65 | NQO2 (0.96) | NQO2ALDH1A1HPGDHSD17B10PRMT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0941991-B1 | 2,4-Bis (4-amidino)phenyl furans as anti-pneumocystis carinii agents | UNIV NORTH CAROLINA (US) | 2001-12-05 | — | — | EP | claimed |
| US-6008247-A | TREATING PNEUMONIA | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 1999-12-28 | — | — | US | claimed |
| EP-0941991-A1 | 2,4-Bis (4-amidino)phenyl furans as anti-pneumocystis carinii agents | UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 1999-09-15 | — | — | EP | claimed |
| EP-1130019-B1 | 2,4-bis((4-Amidino)phenyl)furans as anti-pneumocystis carinii agents | UNIV NORTH CAROLINA (US) | 2004-05-06 | — | — | EP | disclosed |
| EP-0941991-B1 | 2,4-Bis (4-amidino)phenyl furans as anti-pneumocystis carinii agents | UNIV NORTH CAROLINA (US) | 2001-12-05 | — | — | EP | disclosed |
| EP-1130019-A1 | 2,4-bis((4-Amidino)phenyl)furans as anti-pneumocystis carinii agents | UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2001-09-05 | — | — | EP | disclosed |
| US-6127554-A | MAKING 2,4-BIS(HALO-PHENYL)FURAN COMPOUNDS BY REACTING 2,4-BIS(HALO-PHENYL),5-((HALO-PHENYL)CARBONYL)FURAN IN THE PRESENCE OF A BASE; CHEMICAL INTERMEDIATE TO SYNTHESIS OF ANTIMICROBIAL AGENT | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2000-10-03 | — | — | US | disclosed |
| US-6008247-A | TREATING PNEUMONIA | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 1999-12-28 | — | — | US | disclosed |
| EP-0941991-A1 | 2,4-Bis (4-amidino)phenyl furans as anti-pneumocystis carinii agents | UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 1999-09-15 | — | — | EP | disclosed |