SCHEMBL13596286

SCHEMBL13596286

CNCC(=O)NC(C)(C)C

nearest known ligand 0.39

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
MAPT P10636 2/20 0.39
KDM1A O60341 1/20 0.39
POLB P06746 3/20 0.38
HDAC2 Q92769 1/20 0.38
SMN1; SMN2 Q16637 3/20 0.37
ALDH1A1 P00352 3/20 0.37
NPC1 O15118 2/20 0.37
GAA P10253 1/20 0.37
TSHR P16473 1/20 0.35
HPGD P15428 1/20 0.35
EPHX1 P07099 1/20 0.34
LMNA P02545 2/20 0.34
CA1 P00915 2/20 0.34
CA2 P00918 2/20 0.34
CASP3 P42574 1/20 0.34
SENP8 Q96LD8 1/20 0.34
SENP7 Q9BQF6 1/20 0.34
SENP6 Q9GZR1 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL30225271 0.97 MAPT (0.38) MAPTKDM1APOLBHDAC2SMN1; SMN2
SCHEMBL24968519 0.91 MAPT (0.35) MAPTKDM1APOLBHDAC2SMN1; SMN2
SCHEMBL16656672 0.80 CA1 (0.33) CA1CA2
SCHEMBL10101586 0.79 MAPT (0.39) MAPTKDM1APOLBHDAC2SMN1; SMN2
SCHEMBL18026348 0.77 ALDH1A1 (0.47) MAPTPOLBHDAC2SMN1; SMN2ALDH1A1
SCHEMBL12556801 0.77 MAPT (0.38) MAPTKDM1APOLBHDAC2SMN1; SMN2
SCHEMBL9965485 0.75 SMN1; SMN2 (0.39) MAPTKDM1APOLBHDAC2SMN1; SMN2
SCHEMBL2757943 0.75 CACNA1H (0.42) MAPTKDM1APOLBHDAC2SMN1; SMN2
SCHEMBL24279531 0.75 SMN1; SMN2 (0.43) MAPTPOLBHDAC2SMN1; SMN2ALDH1A1
SCHEMBL24629808 0.75 CA1 (0.30) CA1CA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4142732-B1 METHODS OF USE FOR PYRIMIDINES AS FERROPORTIN INHIBITORS GLOBAL BLOOD THERAPEUTICS INC (US) 2026-04-22 EP disclosed
US-20250109122-A1 CYCLOALKYL PYRIMIDINES AS FERROPORTIN INHIBITORS GLOBAL BLOOD THERAPEUTICS INC (US) 2025-04-03 US disclosed
US-12202817-B2 Cycloalkyl pyrimidines as ferroportin inhibitors GLOBAL BLOOD THERAPEUTICS, INC. (US) 2025-01-21 US disclosed
US-20240140932-A1 CYCLOALKYL PYRIMIDINES AS FERROPORTIN INHIBITORS GLOBAL BLOOD THERAPEUTICS INC (US) 2024-05-02 US disclosed
US-11746100-B2 Cycloalkyl pyrimidines as ferroportin inhibitors GLOBAL BLOOD THERAPEUTICS, INC. (US) 2023-09-05 US disclosed
US-11746100-B2 Cycloalkyl pyrimidines as ferroportin inhibitors GLOBAL BLOOD THERAPEUTICS, INC. (US) 2023-09-05 US disclosed
US-11746100-B2 Cycloalkyl pyrimidines as ferroportin inhibitors GLOBAL BLOOD THERAPEUTICS, INC. (US) 2023-09-05 US disclosed
US-20230226074-A1 METHODS OF USE FOR PYRIMIDINES AS FERROPORTIN INHIBITORS GLOBAL BLOOD THERAPEUTICS INC (US) 2023-07-20 US disclosed
US-20230226074-A1 METHODS OF USE FOR PYRIMIDINES AS FERROPORTIN INHIBITORS GLOBAL BLOOD THERAPEUTICS INC (US) 2023-07-20 US disclosed
US-20230226074-A1 METHODS OF USE FOR PYRIMIDINES AS FERROPORTIN INHIBITORS GLOBAL BLOOD THERAPEUTICS INC (US) 2023-07-20 US disclosed
WO-2021222359-A1 THIENO PYRIMIDINES AS FERROPORTIN INHIBITORS GLOBAL BLOOD THERAPEUTICS, INC. (US) 2021-11-04 WO disclosed
WO-2021222483-A1 METHODS OF USE FOR PYRIMIDINES AS FERROPORTIN INHIBITORS GLOBAL BLOOD THERAPEUTICS, INC. (US) 2021-11-04 WO disclosed
WO-2021222363-A1 CYCLOALKYL PYRIMIDINES AS FERROPORTIN INHIBITORS GLOBAL BLOOD THERAPEUTICS, INC. (US) 2021-11-04 WO disclosed
WO-2021222363-A1 CYCLOALKYL PYRIMIDINES AS FERROPORTIN INHIBITORS GLOBAL BLOOD THERAPEUTICS, INC. (US) 2021-11-04 WO disclosed
US-20210107917-A1 BRIDGED BICYCLIC INHIBITORS OF MENIN-MLL AND METHODS OF USE KURA ONCOLOGY, INC. 2021-04-15 US disclosed
US-10752639-B2 Bridged bicyclic inhibitors of menin-MLL and methods of use KURA ONCOLOGY, INC. (US) 2020-08-25 US disclosed
US-20190092783-A1 BRIDGED BICYCLIC INHIBITORS OF MENIN-MLL AND METHODS OF USE KURA ONCOLOGY, INC. (US) 2019-03-28 US disclosed
US-20180193315-A1 SPIROCYCLIC HAT INHIBITORS AND METHODS FOR THEIR USE ABBVIE INC (US) 2018-07-12 US disclosed
US-8940784-B2 Water-soluble CC-1065 analogs and their conjugates SYNTARGA B.V. (NL) 2015-01-27 US disclosed
US-20090318668-A1 Water-Soluble CC-1065 Analogs and Their Conjugates Georg-August-Universität Göttingen Stiftung öffentlichen Rechts (ohne Bereich Humanmedizin) (DE) 2009-12-24 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090318668-A1 Water-Soluble CC-1065 Analogs and Their Conjugates PCNA, DCK, BAD MAPT 4219/4885KDM1A 1506/4885POLB 73/4885
US-20230226074-A1 METHODS OF USE FOR PYRIMIDINES AS FERROPORTIN INHIBITORS SLC40A1, HAMP, SLC19A1 MAPT 4261/4885KDM1A 4532/4885POLB 355/4885
US-12202817-B2 Cycloalkyl pyrimidines as ferroportin inhibitors HAMP, SLC40A1, FANCI MAPT 4441/4885KDM1A 4820/4885POLB 480/4885
US-11746100-B2 Cycloalkyl pyrimidines as ferroportin inhibitors HAMP, SLC40A1, FANCI MAPT 4441/4885KDM1A 4820/4885POLB 480/4885
US-10752639-B2 Bridged bicyclic inhibitors of menin-MLL and methods of use MLLT1, MEN1, MLLT3 MAPT 2565/4885KDM1A 57/4885POLB 2904/4885
US-20180193315-A1 SPIROCYCLIC HAT INHIBITORS AND METHODS FOR THEIR USE KAT2B, HDAC1, KAT2A MAPT 715/4885KDM1A 521/4885POLB 325/4885
US-20210107917-A1 BRIDGED BICYCLIC INHIBITORS OF MENIN-MLL AND METHODS OF USE MLLT1, MEN1, BMI1 MAPT 2655/4885KDM1A 83/4885POLB 3023/4885
US-20250109122-A1 CYCLOALKYL PYRIMIDINES AS FERROPORTIN INHIBITORS HAMP, SLC40A1, FANCI MAPT 4441/4885KDM1A 4820/4885POLB 480/4885
US-20240140932-A1 CYCLOALKYL PYRIMIDINES AS FERROPORTIN INHIBITORS HAMP, SLC40A1, FANCI MAPT 4441/4885KDM1A 4820/4885POLB 480/4885
US-20190092783-A1 BRIDGED BICYCLIC INHIBITORS OF MENIN-MLL AND METHODS OF USE MLLT1, MEN1, BMI1 MAPT 2655/4885KDM1A 83/4885POLB 3023/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.