Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12881476 | 0.86 | MAPT (0.46) | MAPTGAAL3MBTL1POLBALDH1A1 | |
| SCHEMBL12881487 | 0.86 | ACHE (0.45) | MAPTGAATDP1CHRM1L3MBTL1 | |
| SCHEMBL12881496 | 0.86 | L3MBTL1 (0.41) | MAPTGAATDP1CHRM1L3MBTL1 | |
| SCHEMBL13601702 | 0.81 | MAPT (0.49) | MAPTGAAHPGDL3MBTL1POLB | |
| SCHEMBL13601717 | 0.80 | MAPT (0.59) | MAPTHTR1AGAATDP1CYP1A2 | |
| SCHEMBL13601727 | 0.77 | CHRM2 (0.43) | MAPTHTR1AGAATDP1CYP1A2 | |
| SCHEMBL13601729 | 0.74 | MAPT (0.39) | MAPTHTR1AGAATDP1CYP1A2 | |
| SCHEMBL13601724 | 0.74 | MAPT (0.44) | MAPTHTR1AGAATDP1CYP1A2 | |
| SCHEMBL13601613 | 0.73 | ALDH1A1 (0.41) | GAAALDH1A1KDM4E | |
| SCHEMBL13601625 | 0.72 | TP53 (0.43) | MAPTCHRM1L3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7625886-B2 | Selected CGRP antagonists, processes for preparing them and their use as pharmaceutical compositions | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-12-01 | — | — | US | disclosed |