Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | FKBP1A | P62942 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13920579 | 0.85 | KMT2A (0.34) | MAPTFKBP1AALDH1A1CYP3A4CYP2D6 | |
| SCHEMBL9969991 | 0.83 | ALDH1A1 (0.40) | MAPTALDH1A1CYP3A4POLBKDM4E | |
| SCHEMBL13604532 | 0.81 | L3MBTL1 (0.34) | MAPTFKBP1AALDH1A1CYP3A4CYP2D6 | |
| SCHEMBL18084404 | 0.78 | ATM (0.41) | — | |
| SCHEMBL3762837 | 0.76 | MAPT (0.39) | MAPTFKBP1AALDH1A1CYP3A4CYP2D6 | |
| SCHEMBL13920578 | 0.76 | KMT2A (0.34) | MAPTFKBP1AALDH1A1CYP3A4CYP2D6 | |
| SCHEMBL14447727 | 0.76 | MAPT (0.39) | MAPTALDH1A1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL13920585 | 0.75 | MMP2 (0.39) | MAPTFKBP1AALDH1A1CYP3A4CYP2D6 | |
| SCHEMBL13920586 | 0.75 | MMP2 (0.39) | MAPTFKBP1AALDH1A1CYP3A4CYP2D6 | |
| SCHEMBL8440463 | 0.73 | FKBP1A (0.39) | MAPTFKBP1AALDH1A1CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7635697-B2 | Farnesyl protein transferase inhibitors and methods for treating proliferative diseases | SCHERING CORPORATION (US) | 2009-12-22 | — | — | US | disclosed |