Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 3/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6867416 | 0.75 | MEN1 (0.33) | MEN1KMT2AKDM4EALDH1A1LMNA | |
| SCHEMBL3137075 | 0.75 | MEN1 (0.33) | MEN1KMT2A | |
| SCHEMBL13785535 | 0.72 | KDM4E (0.40) | MEN1KMT2AKDM4EALDH1A1LMNA | |
| SCHEMBL5051725 | 0.71 | MEN1 (0.37) | MEN1KMT2AKDM4ENPC1 | |
| SCHEMBL10798452 | 0.70 | KDM4E (0.50) | MEN1KMT2AKDM4EALDH1A1LMNA | |
| SCHEMBL14192193 | 0.69 | CHRM2 (0.34) | CHRM2CHRM1CHRM3 | |
| SCHEMBL12421265 | 0.68 | KMT2A (0.47) | MEN1KMT2AKDM4EALDH1A1LMNA | |
| SCHEMBL1072568 | 0.67 | KDM4E (0.45) | MEN1KMT2AKDM4EALDH1A1LMNA | |
| SCHEMBL8398977 | 0.67 | KDM4E (0.45) | KDM4EALDH1A1LMNANPC1GAA | |
| SCHEMBL14950267 | 0.67 | ALDH1A1 (0.50) | KDM4EALDH1A1LMNANPC1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 63 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12139470-B2 | Trioxolane agents | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2024-11-12 | — | — | US | disclosed |
| US-20220411396-A1 | TRIOXOLANE AGENTS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2022-12-29 | — | — | US | disclosed |
| US-20220411396-A1 | TRIOXOLANE AGENTS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2022-12-29 | — | — | US | disclosed |
| US-20220017559-A1 | CYCLIC PEROXIDES AS PRODRUGS FOR SELECTIVE DELIVERY OF AGENTS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2022-01-20 | — | — | US | disclosed |
| US-11072594-B2 | Trioxolane agents | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2021-07-27 | — | — | US | disclosed |
| US-11072594-B2 | Trioxolane agents | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2021-07-27 | — | — | US | disclosed |
| US-11014955-B2 | Cyclic peroxides as prodrugs for selective delivery of agents | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2021-05-25 | — | — | US | disclosed |
| WO-2020240266-A1 | NEW ENDOPEROXIDE COMPOUNDS, PROCESS FOR OBTAINING THEM AND USES THEREOF FOR CONTROL OF PERKINSIOSIS IN BIVALVES | CCMAR - CENTRO DE CIÊNCIAS DO MAR UNIVERSIDADE DO ALGARVE (PT) | 2020-12-03 | — | — | WO | disclosed |
| WO-2020240266-A1 | NEW ENDOPEROXIDE COMPOUNDS, PROCESS FOR OBTAINING THEM AND USES THEREOF FOR CONTROL OF PERKINSIOSIS IN BIVALVES | CCMAR - CENTRO DE CIÊNCIAS DO MAR UNIVERSIDADE DO ALGARVE (PT) | 2020-12-03 | — | — | WO | disclosed |
| US-20200317714-A1 | CYCLIC PEROXIDES AS PRODRUGS FOR SELECTIVE DELIVERY OF AGENTS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2020-10-08 | — | — | US | disclosed |
| US-20070021423-A1 | Dual molecules containing peroxy derivative, the synthesis and therapeutic applications thereof | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2007-01-25 | — | — | US | disclosed |
| EP-1414813-B1 | 1,2,4-TRIOXOLANE ANTIMALARIALS | MEDICINES MALARIA VENTURE MMV (CH) | 2006-09-13 | — | — | EP | disclosed |
| US-20050256185-A1 | Spiro and dispiro 1,2,4-trioxolane antimalarials | MEDICINES FOR MALARIA VENTURE MMV (CH) | 2005-11-17 | — | — | US | disclosed |
| CN-1626530-A | Spiro and dispiro -1,2,4-trioxalane antimalarials | MEDICINES MALARIA VENTURE MMV (CH) | 2005-06-15 | — | — | CN | disclosed |
| US-6906205-B2 | Spiro and dispiro 1,2,4-trioxolane antimalarials | MEDICINES FOR MALARIA VENTURE MMV (CH) | 2005-06-14 | — | — | US | disclosed |
| EP-1514871-A1 | Dispiro 1,2,4 - trioxolane antimalarials | Medicines for Malaria Venture (CH) | 2005-03-16 | — | — | EP | disclosed |
| US-6825230-B2 | PEROXY COMPOUNDS SUCH AS ADAMANTANE-2-SPIRO-3'-8'-((1'S)-10'-CAMPHORSULFONYL)-1',2',4'-TRIOXA-8' -AZASPIRO(4.5) DECANE, USED FOR PROPHYLAXIS OF MALARIA OR SCHISTOSOMIASIS INFECTIONS | MEDICINES FOR MALARIA VENTURE MMV (CH) | 2004-11-30 | — | — | US | disclosed |
| CN-1545508-A | 1,2,4-trioxolane antimalarials | ű��ҩ�﹫˾ | 2004-11-10 | — | — | CN | disclosed |
| US-20040186168-A1 | Such as spiroadamantane on one side and 4-substituted spiro-cyclohexyl on other side; structurally simple, nontoxic, easy synthesis, potent parasiticides | MEDICINES FOR MALARIA VENTURE MMV (CH) | 2004-09-23 | — | — | US | disclosed |
| US-20040039008-A1 | Spiro and dispiro 1,2,4-trioxolane antimalarials | MEDICINES FOR MALARIA VENTURES MMV (CH) | 2004-02-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220411396-A1 | TRIOXOLANE AGENTS | ABCB4, SLC10A1, SLC10A2 | MEN1 2610/4885KMT2A 3654/4885KDM4E 4796/4885 |
| US-11072594-B2 | Trioxolane agents | ABCB4, SLC10A1, SLC10A2 | MEN1 2610/4885KMT2A 3654/4885KDM4E 4796/4885 |
| US-12139470-B2 | Trioxolane agents | ABCB4, SLC10A1, SLC10A2 | MEN1 2610/4885KMT2A 3654/4885KDM4E 4796/4885 |
| US-11014955-B2 | Cyclic peroxides as prodrugs for selective delivery of agents | GPX4, PRDX1, PRDX3 | MEN1 4056/4885KMT2A 3813/4885KDM4E 3845/4885 |
| US-20070021423-A1 | Dual molecules containing peroxy derivative, the synthesis and therapeutic applications thereof | PRDX2, PRDX1, PRDX5 | MEN1 3607/4885KMT2A 3568/4885KDM4E 2845/4885 |
| US-20220017559-A1 | CYCLIC PEROXIDES AS PRODRUGS FOR SELECTIVE DELIVERY OF AGENTS | GPX4, PRDX1, PRDX3 | MEN1 4056/4885KMT2A 3813/4885KDM4E 3845/4885 |
| US-20040039008-A1 | Spiro and dispiro 1,2,4-trioxolane antimalarials | DHODH, THPO, SQLE | MEN1 788/4885KMT2A 3704/4885KDM4E 4113/4885 |
| US-20040186168-A1 | Such as spiroadamantane on one side and 4-substituted spiro-cyclohexyl on other side; structurally simple, nontoxic, easy synthesis, potent parasiticides | DHODH, SQLE, SULT1E1 | MEN1 793/4885KMT2A 3756/4885KDM4E 3092/4885 |
| US-20200317714-A1 | CYCLIC PEROXIDES AS PRODRUGS FOR SELECTIVE DELIVERY OF AGENTS | GPX4, PRDX1, GPX1 | MEN1 4109/4885KMT2A 3571/4885KDM4E 3838/4885 |
| US-20050256185-A1 | Spiro and dispiro 1,2,4-trioxolane antimalarials | DHODH, THPO, SQLE | MEN1 788/4885KMT2A 3704/4885KDM4E 4113/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.