Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.46 |
| ▸ | MEN1 | O00255 | 5/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 3/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | PGR | P06401 | 3/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | DHFR | P00374 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | GUSB | P08236 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 2/20 | 0.36 |
| ▸ | CA1 | P00915 | 2/20 | 0.36 |
| ▸ | CA2 | P00918 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5177359 | 0.82 | ALDH1A1 (0.54) | ALDH1A1MEN1KMT2AGAARXFP1 | |
| SCHEMBL5205016 | 0.82 | ALDH1A1 (0.46) | ALDH1A1MEN1KMT2AKDM4EGAA | |
| SCHEMBL9567855 | 0.80 | ALDH1A1 (0.54) | ALDH1A1MEN1KMT2AGAARXFP1 | |
| SCHEMBL5176626 | 0.80 | ALDH1A1 (0.54) | ALDH1A1MEN1KMT2AGAARXFP1 | |
| SCHEMBL17306470 | 0.74 | KDM4E (0.44) | ALDH1A1MEN1KMT2AKDM4EGAA | |
| SCHEMBL5177579 | 0.73 | ALDH1A1 (0.46) | ALDH1A1MEN1KMT2AKDM4EGAA | |
| SCHEMBL27404601 | 0.71 | ALDH1A1 (0.44) | ALDH1A1MEN1KMT2AKDM4EGAA | |
| SCHEMBL9864478 | 0.70 | ALDH1A1 (0.63) | ALDH1A1MEN1KMT2AKDM4ERXFP1 | |
| SCHEMBL5178013 | 0.69 | KMT2A (0.55) | ALDH1A1MEN1KMT2AKDM4EGAA | |
| SCHEMBL5696233 | 0.69 | DHFR (0.54) | ALDH1A1MEN1KMT2AKDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8796266-B2 | Cyclothiocarbamate derivatives as progesterone receptor modulators | WYETH LLC (US) | 2014-08-05 | — | — | US | disclosed |
| US-8796266-B2 | Cyclothiocarbamate derivatives as progesterone receptor modulators | WYETH LLC (US) | 2014-08-05 | — | — | US | disclosed |
| US-20130261112-A1 | Cyclothiocarbamate Derivatives as Progesterone Receptor Modulators | WYETH LLC | 2013-10-03 | — | — | US | disclosed |
| US-20130261112-A1 | Cyclothiocarbamate Derivatives as Progesterone Receptor Modulators | WYETH LLC | 2013-10-03 | — | — | US | disclosed |
| US-8466146-B2 | Cyclothiocarbamate derivatives as progesterone receptor modulators | WYETH LLC (US) | 2013-06-18 | — | — | US | disclosed |
| US-8466146-B2 | Cyclothiocarbamate derivatives as progesterone receptor modulators | WYETH LLC (US) | 2013-06-18 | — | — | US | disclosed |
| US-20130072480-A1 | Cyclothiocarbamate Derivatives as Progesterone Receptor Modulators | WYETH LLC (US) | 2013-03-21 | — | — | US | disclosed |
| US-20130072480-A1 | Cyclothiocarbamate Derivatives as Progesterone Receptor Modulators | WYETH LLC (US) | 2013-03-21 | — | — | US | disclosed |
| US-8329690-B2 | Cyclothiocarbamate derivatives as progesterone receptor modulators | WYETH LLC (US) | 2012-12-11 | — | — | US | disclosed |
| US-8329690-B2 | Cyclothiocarbamate derivatives as progesterone receptor modulators | WYETH LLC (US) | 2012-12-11 | — | — | US | disclosed |
| US-20090281096-A1 | CYCLOTHIOCARBAMATE DERIVATIVES AS PROGESTERONE RECEPTOR MODULATORS | WYETH (US) | 2009-11-12 | — | — | US | disclosed |
| US-20090281096-A1 | CYCLOTHIOCARBAMATE DERIVATIVES AS PROGESTERONE RECEPTOR MODULATORS | WYETH (US) | 2009-11-12 | — | — | US | disclosed |
| US-7569564-B2 | Cyclothiocarbamate derivatives as progesterone receptor modulators | WYETH (US) | 2009-08-04 | — | — | US | disclosed |
| US-7569564-B2 | Cyclothiocarbamate derivatives as progesterone receptor modulators | WYETH (US) | 2009-08-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090281096-A1 | CYCLOTHIOCARBAMATE DERIVATIVES AS PROGESTERONE RECEPTOR MODULATORS | PGR, PGRMC2, PGRMC1 | ALDH1A1 3042/4885MEN1 4319/4885KMT2A 3073/4885 |
| US-20130072480-A1 | Cyclothiocarbamate Derivatives as Progesterone Receptor Modulators | PGR, PGRMC2, PGRMC1 | ALDH1A1 3042/4885MEN1 4319/4885KMT2A 3073/4885 |
| US-20130261112-A1 | Cyclothiocarbamate Derivatives as Progesterone Receptor Modulators | PGR, PGRMC2, PGRMC1 | ALDH1A1 3042/4885MEN1 4319/4885KMT2A 3073/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.