Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.55 |
| ▸ | GAA | P10253 | 2/20 | 0.55 |
| ▸ | PRCP | P42785 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | GUSB | P08236 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
| ▸ | MC4R | P32245 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.42 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9567855 | 0.86 | ALDH1A1 (0.54) | KMT2AGAAPRCPALDH1A1MAPT | |
| SCHEMBL5176626 | 0.86 | ALDH1A1 (0.54) | KMT2AGAAPRCPALDH1A1MAPT | |
| SCHEMBL5177579 | 0.81 | ALDH1A1 (0.46) | KMT2AGAAALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL5205016 | 0.81 | ALDH1A1 (0.46) | KMT2AGAAALDH1A1KDM4EMAPT | |
| SCHEMBL25141969 | 0.80 | ALDH1A1 (0.39) | KMT2AGAAALDH1A1KDM4EMAPT | |
| SCHEMBL5696233 | 0.74 | DHFR (0.54) | KMT2AGAAALDH1A1KDM4EL3MBTL1 | |
| SCHEMBL5177430 | 0.74 | MAPT (0.50) | KMT2AGAAALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL5696272 | 0.72 | CHRM1 (0.42) | KMT2AGAAALDH1A1KDM4EMAPT | |
| SCHEMBL5696249 | 0.71 | DHFR (0.51) | ALDH1A1SMN1; SMN2GUSBHTTTSHR | |
| SCHEMBL5696173 | 0.70 | DHFR (0.50) | KMT2AALDH1A1SMN1; SMN2MAPTGUSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1807402-A1 | QUINAZOLINE DERIVATIVES, PROCESS FOR THEIR PREPARATION, THEIR USE AS ANTIMITOTICS AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAID DERIVATIVES | EMBL (DE) | 2007-07-18 | — | — | EP | disclosed |
| WO-2006048308-A1 | QUINAZOLINE DERIVATIVES, PROCESS FOR THEIR PREPARATION, THEIR USE AS ANTIMITOTICS AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAID DERIVATIVES | EMBL (DE) | 2006-05-11 | — | — | WO | disclosed |