Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | TRPM5 | Q9NZQ8 | 3/20 | 0.41 |
| ▸ | TRPM4 | Q8TD43 | 2/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | KIF11 | P52732 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | DHFR | P00374 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | BCHE | P06276 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | GUSB | P08236 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5205016 | 0.88 | ALDH1A1 (0.46) | ALDH1A1KMT2AGAATRPM5TRPM4 | |
| SCHEMBL5696249 | 0.86 | DHFR (0.51) | ALDH1A1KIF11SMN1; SMN2DHFRHTR2A | |
| SCHEMBL5178013 | 0.81 | KMT2A (0.55) | ALDH1A1KMT2AGAAALOX12MEN1 | |
| SCHEMBL9567855 | 0.80 | ALDH1A1 (0.54) | ALDH1A1KMT2AGAAMEN1MAPT | |
| SCHEMBL5176626 | 0.80 | ALDH1A1 (0.54) | ALDH1A1KMT2AGAAMEN1MAPT | |
| SCHEMBL5696173 | 0.76 | DHFR (0.50) | ALDH1A1KMT2ATRPM5TRPM4ALOX12 | |
| SCHEMBL13612701 | 0.73 | ALDH1A1 (0.46) | ALDH1A1KMT2AGAAMEN1KDM4E | |
| SCHEMBL29357488 | 0.72 | DHFR (0.54) | ALDH1A1KMT2AGAAKIF11MEN1 | |
| SCHEMBL5177430 | 0.72 | MAPT (0.50) | ALDH1A1KMT2AGAATRPM5ALOX12 | |
| SCHEMBL5696233 | 0.72 | DHFR (0.54) | ALDH1A1KMT2AGAAKIF11MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1807402-A1 | QUINAZOLINE DERIVATIVES, PROCESS FOR THEIR PREPARATION, THEIR USE AS ANTIMITOTICS AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAID DERIVATIVES | EMBL (DE) | 2007-07-18 | — | — | EP | disclosed |
| WO-2006048308-A1 | QUINAZOLINE DERIVATIVES, PROCESS FOR THEIR PREPARATION, THEIR USE AS ANTIMITOTICS AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAID DERIVATIVES | EMBL (DE) | 2006-05-11 | — | — | WO | disclosed |
| EP-0564397-A1 | Antiatherosclerotic substituted phenylquinazoline derivatives | SANDOZ LTD. (CH) | 1993-10-06 | — | — | EP | disclosed |
| CN-1076445-A | The phenylquinazoline derivates that replaces | SANDOZ LTD (US) | 1993-09-22 | — | — | CN | disclosed |