Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | USP7 | Q93009 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.38 |
| ▸ | DPP4 | P27487 | 3/20 | 0.38 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.38 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | JAK1 | P23458 | 1/20 | 0.37 |
| ▸ | TYK2 | P29597 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13616805 | 0.78 | MPL (0.47) | ALDH1A1KDM4EHSD17B10NPC1USP7 | |
| SCHEMBL13616946 | 0.78 | ADORA2A (0.40) | ALDH1A1KDM4EHSD17B10NPC1RAB9A | |
| SCHEMBL2093838 | 0.78 | CYP19A1 (0.38) | ALDH1A1HPGDKDM4EHSD17B10NPC1 | |
| SCHEMBL2093842 | 0.78 | HSD11B1 (0.43) | ALDH1A1HPGDKDM4EHSD17B10NPC1 | |
| SCHEMBL13398544 | 0.73 | KDM4E (0.63) | ALDH1A1KDM4ENPC1RAB9ASMN1; SMN2 | |
| SCHEMBL13616783 | 0.72 | KDM4E (0.53) | ALDH1A1KDM4ENPC1RAB9ASMN1; SMN2 | |
| SCHEMBL13616971 | 0.71 | MPL (0.38) | ALDH1A1KDM4ESMN1; SMN2LMNAJAK2 | |
| SCHEMBL13616873 | 0.70 | CLK1 (0.37) | ALDH1A1KDM4ELMNADPP4TSHR | |
| SCHEMBL15692562 | 0.69 | KDM4E (0.50) | ALDH1A1HPGDKDM4EHSD17B10NPC1 | |
| SCHEMBL13616809 | 0.68 | DHFR (0.47) | CYP19A1DPP4LIMK1JAK2MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2119716-A1 | AZA-BRIDGED-RING COMPOUND | Astellas Pharma Inc. (JP) | 2009-11-18 | — | — | EP | disclosed |