Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FBP1 | P09467 | 4/20 | 0.36 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.35 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.35 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.35 |
| ▸ | NOS3 | P29474 | 2/20 | 0.35 |
| ▸ | NOS1 | P29475 | 2/20 | 0.35 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA3 | P07451 | 1/20 | 0.34 |
| ▸ | CA6 | P23280 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.34 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.34 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.34 |
| ▸ | MMP1 | P03956 | 2/20 | 0.33 |
| ▸ | MMP2 | P08253 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13619916 | 0.84 | MMP1 (0.38) | FBP1CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL16727254 | 0.81 | FBP1 (0.36) | FBP1CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL13619909 | 0.78 | FBP1 (0.39) | FBP1CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL16730128 | 0.77 | SLC6A2 (0.36) | FBP1CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL13619906 | 0.75 | L3MBTL1 (0.46) | NOS1CA2ALDH1A1CA12CA3 | |
| SCHEMBL13619910 | 0.74 | FBP1 (0.36) | FBP1NOS3NOS1NR1H3CA2 | |
| SCHEMBL13619926 | 0.72 | TSHR (0.42) | FBP1CA2CA12CA3CA6 | |
| SCHEMBL13619927 | 0.72 | NR1H3 (0.41) | FBP1NOS3NOS1NR1H3CA2 | |
| SCHEMBL13367597 | 0.69 | CYP2A6 (0.46) | CHRNB2CHRNB4CHRNA3CHRNA4NOS3 | |
| SCHEMBL151519 | 0.69 | ALDH1A1 (0.46) | CHRNB2CHRNB4CHRNA3CHRNA4NOS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150141378-A1 | NITROXYL PROGENITOR COMPOUNDS AND METHODS OF USE | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2015-05-21 | — | — | US | disclosed |
| US-20090281067-A1 | Nitroxyl progenitor compounds and methods of use | THE JOHN HOPKINS UNIVERSITY (US) | 2009-11-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090281067-A1 | Nitroxyl progenitor compounds and methods of use | HMOX2, NNMT, HMOX1 | FBP1 1637/4885CHRNB2 1036/4885CHRNB4 1286/4885 |
| US-20150141378-A1 | NITROXYL PROGENITOR COMPOUNDS AND METHODS OF USE | HMOX2, NNMT, HMOX1 | FBP1 1637/4885CHRNB2 1036/4885CHRNB4 1286/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.