Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A | P35348 | 3/20 | 0.46 |
| ▸ | HTR2A | P28223 | 2/20 | 0.46 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.46 |
| ▸ | MIF | P14174 | 1/20 | 0.46 |
| ▸ | HTR2B | P41595 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 4/20 | 0.39 |
| ▸ | LMNA | P02545 | 4/20 | 0.39 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 3/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.36 |
| ▸ | THPO | P40225 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | RGS12 | O14924 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13934964 | 0.84 | KMT2A (0.47) | ADRA1AHTR2AADRB1MIFHTR2B | |
| SCHEMBL6843601 | 0.84 | ADRA1A (0.54) | ADRA1AHTR2AADRB1MIFHTR2B | |
| SCHEMBL21160722 | 0.79 | PGK1 (0.37) | ADRA1AHTR2AADRB1MIFHTR2B | |
| SCHEMBL458729 | 0.79 | HDAC4 (0.47) | KDM4EHIF1ALMNAALDH1A1TSHR | |
| SCHEMBL6055100 | 0.77 | KDM4E (0.50) | ADRA1AHTR2AADRB1MIFHTR2B | |
| SCHEMBL28648350 | 0.77 | HDAC4 (0.32) | ADRA1AHTR2AADRB1MIFHTR2B | |
| SCHEMBL13620753 | 0.76 | ADRB1 (0.74) | ADRA1AHTR2AADRB1MIFHTR2B | |
| SCHEMBL6055386 | 0.76 | ACHE (0.48) | ADRA1AHTR2AADRB1MIFHTR2B | |
| SCHEMBL24452119 | 0.76 | ADRB1 (0.38) | ADRA1AHTR2AADRB1MIFHTR2B | |
| SCHEMBL10822537 | 0.76 | ADRB1 (0.38) | ADRA1AHTR2AADRB1MIFHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009142967-A1 | THERAPEUTIC PROSTAGLANDIN COMPOUNDS USED AS OCULAR HYPOTENSIVE AGENTS | ALLERGAN, INC. (US) | 2009-11-26 | — | — | WO | disclosed |