SCHEMBL136276

SCHEMBL136276

NC(=O)NS(=O)(=O)c1ncccn1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 1/20 0.40
KMT2A Q03164 1/20 0.40
PTGS2 P35354 5/20 0.40
P2RX7 Q99572 2/20 0.39
EGFR P00533 4/20 0.38
PTGS1 P23219 2/20 0.37
MMP2 P08253 1/20 0.36
MMP14 P50281 1/20 0.36
AURKA O14965 1/20 0.35
DHFR P00374 1/20 0.35
LMNA P02545 1/20 0.35
TSHR P16473 1/20 0.35
PKM P14618 1/20 0.33
HTT P42858 1/20 0.33
L3MBTL1 Q9Y468 1/20 0.33
P4HTM Q9NXG6 1/20 0.33
HDAC3 O15379 1/20 0.33
HDAC4 P56524 1/20 0.33
HDAC1 Q13547 1/20 0.33
HDAC7 Q8WUI4 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL134193 0.83 MEN1 (0.34) MEN1KMT2AP2RX7MMP2MMP14
SCHEMBL29268539 0.83 KMT2A (0.42) MEN1KMT2APTGS2P2RX7EGFR
SCHEMBL729640 0.79 L3MBTL1 (0.50) MEN1KMT2APTGS2PTGS1MMP2
SCHEMBL10571569 0.78 KDM4E (0.39) MEN1KMT2APTGS2EGFRLMNA
SCHEMBL12000995 0.75 CA1 (0.44) MEN1KMT2APTGS2EGFRMMP2
SCHEMBL7456332 0.73 ALDH1A1 (0.39) MEN1KMT2AP2RX7EGFR
SCHEMBL29268541 0.72 PTGS2 (0.36) PTGS2P2RX7EGFRPTGS1PKM
SCHEMBL14645410 0.71 GAA (0.45) HDAC6
SCHEMBL914628 0.71 CSNK1A1 (0.35) MEN1KMT2AMMP2MMP14
SCHEMBL7081766 0.71 NLRP3 (0.50) MEN1KMT2ALMNAL3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1147 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024110852-A1 A HERBICIDAL COMPOSITION AND A PROCESS FOR PREPARING THE SAME THEREOF UPL LIMITED (IN) 2024-05-30 WO claimed
US-20220151229-A1 Synergistic Herbicidal Combinations CLARIANT INTERNATIONAL LTD. (CH) 2022-05-19 US claimed
EP-3930466-A1 SYNERGISTIC HERBICIDAL COMBINATIONS Clariant International Ltd (CH) 2022-01-05 EP claimed
US-20210163451-A1 METHODS AND COMPOSITIONS FOR SUBSTITUTED 2,5-DIKETOPIPERAZINE ANALOGS UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. 2021-06-03 US claimed
US-20190116786-A1 CONTROLLED RELEASE FORMULATIONS OF HERBICIDES HICAP FORMULATIONS LTD (GB) 2019-04-25 US claimed
US-20170118931-A1 PREVENTION OF ROOT INTRUSION IN SUB-SURFACE STRUCTURES IRRIGATION & WATER TECHNOLOGIES IP PTY LTD (AU) 2017-05-04 US claimed
US-20160326540-A1 Methods and Compositions Employing a Sulfonylurea-Dependent Stabilization Domain PIONEER HI-BRED INTERNATIONAL, INC. 2016-11-10 US claimed
US-20160262379-A1 CONTROLLED RELEASE FORMULATIONS OF HERBICIDES HICAP FORMULATIONS LTD (GB) 2016-09-15 US claimed
CN-105473721-A Methods and compositions employing a sulfonylurea-dependent stabilization domain PIONEER HI BRED INT 2016-04-06 CN claimed
CN-105473722-A Methods and compositions to improve the spread of chemical signals in plants PIONEER HI BRED INT 2016-04-06 CN claimed
WO-2010022251-A2 GABA/PESTICIDAL COMBINATIONS PLANT HEALTH CARE, INC. (US) 2010-02-25 WO claimed
US-20100048397-A1 GABA/Pesticidal Combinations PLANT HEALTH CARE, INC. 2010-02-25 US claimed
US-20080254983-A1 Herbicide Composition NUFARM AUSTRALIA LIMITED (AU) 2008-10-16 US claimed
EP-1933621-A1 HERBICIDE COMPOSITION NUFARM AUSTRALIA LIMITED (AU) 2008-06-25 EP claimed
WO-2007030887-A1 HERBICIDE COMPOSITION NUFARM AUSTRALIA LIMITED (AU) 2007-03-22 WO claimed
US-20060183638-A1 Safer control of broadleaf weeds in turf with granular formulations of ALS inhibiting herbicides CORTEVA AGRISCIENCE LLC 2006-08-17 US claimed
WO-2006081441-A1 WASTE TREATMENT BY IN-CONTAINER VITRIFICATION GEOSAFE CORPORATION (US) 2006-08-03 WO claimed
WO-2006016882-A2 METHODS AND MATERIALS FOR ENHANCING THE EFFECTS OF PROTEIN MODULATORS NDSU RESEARCH FOUNDATION (US) 2006-02-16 WO claimed
US-20060009918-A1 Methods and materials for enhancing the effects of protein modulators NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR 2006-01-12 US claimed
US-4944792-A HERBICIDES CIBA-GEIGY CORPORATION (US) 1990-07-31 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220151229-A1 Synergistic Herbicidal Combinations GRM1, FFAR1, GRM2 MEN1 1299/4885KMT2A 985/4885PTGS2 1537/4885
US-20080254983-A1 Herbicide Composition DDT, HDHD5, CUL5 MEN1 4300/4885KMT2A 1394/4885PTGS2 2466/4885
US-20210163451-A1 METHODS AND COMPOSITIONS FOR SUBSTITUTED 2,5-DIKETOPIPERAZINE ANALOGS TKT, HAAO, TALDO1 MEN1 3193/4885KMT2A 1039/4885PTGS2 2497/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.