SCHEMBL914628

SCHEMBL914628

NC(=O)NS(=O)(=O)c1ncc[nH]1

nearest known ligand 0.43

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
CSNK1A1 P48729 1/20 0.35
TYRO3 Q06418 1/20 0.35
DYRK1B Q9Y463 1/20 0.35
MMP2 P08253 1/20 0.32
MMP14 P50281 1/20 0.32
KDM4E B2RXH2 2/20 0.32
ALDH1A1 P00352 2/20 0.32
MEN1 O00255 1/20 0.32
KMT2A Q03164 1/20 0.32
FDPS P14324 1/20 0.31
TXNRD1 Q16881 1/20 0.31
NPC1 O15118 1/20 0.30
RAB9A P51151 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9371507 0.80 ALDH1A1 (0.32) KDM4EALDH1A1FDPSTXNRD1
SCHEMBL12000999 0.77 CA1 (0.34) MMP2KDM4EALDH1A1FDPSTXNRD1
SCHEMBL2423763 0.74 CA12 (0.40) KDM4EALDH1A1NPC1RAB9A
SCHEMBL11450204 0.73 SMN1; SMN2 (0.38) KDM4EALDH1A1TXNRD1
SCHEMBL9368376 0.73 TXNRD1 (0.33) ALDH1A1FDPSTXNRD1
SCHEMBL136276 0.71 MEN1 (0.40) MMP2MMP14MEN1KMT2A
SCHEMBL329285 0.70
SCHEMBL30821606 0.70 L3MBTL1 (0.38) CSNK1A1TYRO3DYRK1BKDM4EALDH1A1
SCHEMBL626944 0.70
SCHEMBL502541 0.69 TXNRD1 (0.44) KDM4EALDH1A1FDPSTXNRD1NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 54 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9801374-B2 Active compound combinations comprising carboxamide derivatives BAYER CROPSCIENCE AG (DE) 2017-10-31 US disclosed
US-20150245610-A1 ACTIVE COMPOUND COMBINATIONS COMPRISING CARBOXAMIDE DERIVATIVES BAYER CROPSCIENCE AG (DE) 2015-09-03 US disclosed
EP-2908639-A1 ACTIVE COMPOUND COMBINATIONS COMPRISING CARBOXAMIDE DERIVATIVES Bayer Cropscience AG (DE) 2015-08-26 EP disclosed
US-9102623-B2 Pyridinecarboxamides, useful-plant-protecting composition comprising them and processes for their preparation and their use BAYER CROPSCIENCE AG (DE) 2015-08-11 US disclosed
CN-101674727-B Pyridonecarboxamides crop protection agents containing the same method for production and use thereof BAYER CROPSCIENCE AG 2014-06-25 CN disclosed
WO-2014060502-A1 ACTIVE COMPOUND COMBINATIONS COMPRISING CARBOXAMIDE DERIVATIVES BAYER CROPSCIENCE AG (DE) 2014-04-24 WO disclosed
EP-2675277-A1 SYNERGISTIC COMBINATIONS CONTAINING A DITHIINO-TETRACARBOXAMIDE FUNGICIDE AND A HERBICIDE, SAFENER OR PLANT GROWTH REGULATOR Bayer Intellectual Property GmbH (DE) 2013-12-25 EP disclosed
US-20130316901-A1 SYNERGISTIC COMBINATIONS CONTAINING A DITHINO-TETRACARBOXAMIDE FUNGICIDE AND A HERBICIDE, SAFENER OR PLANT GROWTH REGULATOR BAYER INTELLECTUAL PROPERTY GMBH (DE) 2013-11-28 US disclosed
US-20120252670-A1 PYRIDINECARBOXAMIDES, USEFUL-PLANT-PROTECTING COMPOSITION COMPRISING THEM AND PROCESSES FOR THEIR PREPARATION AND THEIR USE ZIEMER FRANK (DE) 2012-10-04 US disclosed
WO-2012110517-A1 SYNERGISTIC COMBINATIONS CONTAINING A DITHIINO-TETRACARBOXAMIDE FUNGICIDE AND A HERBICIDE, SAFENER OR PLANT GROWTH REGULATOR BAYER CROPSCIENCE AG (DE) 2012-08-23 WO disclosed
US-20020016263-A1 Liquid formulations AVENTIS CROPSCIENCE GMBH (DE) 2002-02-07 US disclosed
US-6251827-B1 MIXTURE OF PLANT SAFENING AGENT AND ONE OR MORE PESTICIDES HOECHST SCHERING AGREVO GMBH (DE) 2001-06-26 US disclosed
US-6235680-B1 REDUCING SIDE EFFECT OF PESTICIDE HOECHST SCHERING AGREVO GMBH (DE) 2001-05-22 US disclosed
US-5972839-A MIXTURE WITH PLANT SAFENING AGENT HOECHST SCHERING AGREVO GMBH (DE) 1999-10-26 US disclosed
EP-0249938-B1 Imidazolesulfonamide derivatives, herbicides and a method for inhibiting growth of undesirable plants NISSAN CHEMICAL IND LTD (JP) 1994-12-14 EP disclosed
US-4946496-A PLANT GROWTH REGULATORS E. I. DU PONT DE NEMOURS AND COMPANY (US) 1990-08-07 US disclosed
US-4931081-A Herbicidal diazoles sulfonamides E. I. DU PONT DE NEMOURS AND COMPANY (US) 1990-06-05 US disclosed
US-4931081-A Herbicidal diazoles sulfonamides E. I. DU PONT DE NEMOURS AND COMPANY (US) 1990-06-05 US disclosed
US-4830660-A Imidazolesulfonamide derivatives and herbicides NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 1989-05-16 US disclosed
EP-0249938-A2 Imidazolesulfonamide derivatives, herbicides and a method for inhibiting growth of undesirable plants NISSAN CHEMICAL INDUSTRIES LTD. (JP) 1987-12-23 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120252670-A1 PYRIDINECARBOXAMIDES, USEFUL-PLANT-PROTECTING COMPOSITION COMPRISING THEM AND PROCESSES FOR THEIR PREPARATION AND THEIR USE CYC1, CYCS, CBR3 CSNK1A1 1387/4885TYRO3 4817/4885DYRK1B 4151/4885
US-20150245610-A1 ACTIVE COMPOUND COMBINATIONS COMPRISING CARBOXAMIDE DERIVATIVES AADAC, PFAS, CBR3 CSNK1A1 1024/4885TYRO3 2783/4885DYRK1B 2606/4885
US-20130316901-A1 SYNERGISTIC COMBINATIONS CONTAINING A DITHINO-TETRACARBOXAMIDE FUNGICIDE AND A HERBICIDE, SAFENER OR PLANT GROWTH REGULATOR DDT, ING2, DNER CSNK1A1 3338/4885TYRO3 2452/4885DYRK1B 169/4885
US-20020016263-A1 Liquid formulations SLC25A1, SLC16A1, OTC CSNK1A1 2383/4885TYRO3 4849/4885DYRK1B 4084/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.