Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LIPG | Q9Y5X9 | 2/20 | 0.41 |
| ▸ | LPL | P06858 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.33 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.33 |
| ▸ | FAAH | O00519 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1632683 | 0.83 | KDM4E (0.48) | KDM4EALDH1A1MAPK1SMN1; SMN2NPSR1 | |
| SCHEMBL3045151 | 0.81 | LIPG (0.47) | LIPGLPLKDM4EALDH1A1MAPK1 | |
| SCHEMBL1362390 | 0.78 | FAAH (0.41) | KDM4EALDH1A1FAAHLMNAMAPT | |
| SCHEMBL25425656 | 0.77 | LIPG (0.40) | LIPGLPLKDM4EALDH1A1MAPK1 | |
| SCHEMBL1363050 | 0.76 | LIPG (0.39) | LIPGLPLKDM4EALDH1A1NPSR1 | |
| SCHEMBL3399375 | 0.76 | LIPG (0.42) | LIPGLPLMEN1KMT2A | |
| SCHEMBL3041956 | 0.76 | GLS (0.47) | LIPGLPLALDH1A1PRMT5WDR77 | |
| SCHEMBL29964482 | 0.76 | GLS (0.47) | LIPGLPLALDH1A1PRMT5WDR77 | |
| SCHEMBL3399142 | 0.76 | LIPG (0.42) | LIPGLPLMEN1KMT2A | |
| SCHEMBL1631726 | 0.75 | CYP2E1 (0.40) | KDM4EALDH1A1CYP2C9FAAHLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8067408-B2 | Dual pharmacophores—PDE4-muscarinic antagonistics | GLAXO GROUP LIMITED (GB) | 2011-11-29 | — | — | US | disclosed |