Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.36 |
| ▸ | KLK1 | P06870 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | CASP7 | P55210 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13162600 | 0.90 | KMT2A (0.49) | GRM2JAK2JAK1KMT2AKLKB1 | |
| SCHEMBL13634404 | 0.87 | LMNA (0.46) | GRM2KMT2ALMNAALDH1A1GAA | |
| SCHEMBL13634407 | 0.84 | KMT2A (0.52) | KMT2ALMNAMCHR1KDM4EALDH1A1 | |
| SCHEMBL13163941 | 0.84 | ALDH1A1 (0.53) | GRM2JAK2JAK1KMT2ALMNA | |
| SCHEMBL13162385 | 0.81 | KMT2A (0.48) | GRM2JAK2JAK1KMT2APOLB | |
| SCHEMBL13634720 | 0.79 | IRAK4 (0.47) | GRM2JAK2JAK1KMT2AALDH1A1 | |
| SCHEMBL13634241 | 0.78 | LMNA (0.48) | KMT2ALMNAPOLBALDH1A1SMN1; SMN2 | |
| SCHEMBL13638972 | 0.78 | KMT2A (0.46) | GRM2JAK2JAK1KMT2ALMNA | |
| SCHEMBL13634718 | 0.78 | IRAK4 (0.47) | KMT2AL3MBTL1 | |
| SCHEMBL13634362 | 0.77 | CCNE2 (0.48) | GRM2JAK2JAK1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8304547-B2 | Azolecarboxamide compound or salt thereof | ASTELLAS PHARMA INC. (JP) | 2012-11-06 | — | — | US | disclosed |