Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 1/20 | 0.42 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | ERN1 | O75460 | 1/20 | 0.32 |
| ▸ | NOS1 | P29475 | 1/20 | 0.32 |
| ▸ | NCF1 | P14598 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | BRD4 | O60885 | 1/20 | 0.30 |
| ▸ | CCL2 | P13500 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13638864 | 0.84 | GRM2 (0.46) | GRM2PDE1BJAK2JAK1ALDH1A1 | |
| SCHEMBL13638957 | 0.80 | HRH3 (0.49) | ALDH1A1LMNAMAPTKCNJ1SMN1; SMN2 | |
| SCHEMBL13638972 | 0.73 | KMT2A (0.46) | GRM2PDE1BJAK2JAK1ALDH1A1 | |
| SCHEMBL13638959 | 0.72 | SIGMAR1 (0.52) | KCNJ1ERN1MEN1KMT2A | |
| SCHEMBL2561365 | 0.71 | GRM2 (0.42) | GRM2PDE1BJAK2JAK1ALDH1A1 | |
| SCHEMBL13638752 | 0.71 | GRM2 (0.43) | GRM2BRD4CCL2 | |
| SCHEMBL13638850 | 0.70 | KMT2A (0.42) | GRM2JAK2JAK1ALDH1A1LMNA | |
| SCHEMBL6132960 | 0.70 | JAK2 (0.44) | GRM2PDE1BJAK2JAK1ALDH1A1 | |
| SCHEMBL13164038 | 0.69 | GRM2 (0.45) | GRM2PDE1BJAK2JAK1SMN1; SMN2 | |
| SCHEMBL13162328 | 0.69 | ALDH1A1 (0.37) | GRM2ALDH1A1LMNAMAPTKCNJ1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8304547-B2 | Azolecarboxamide compound or salt thereof | ASTELLAS PHARMA INC. (JP) | 2012-11-06 | — | — | US | disclosed |