Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | IL6 | P05231 | 6/20 | 0.35 |
| ▸ | DRD2 | P14416 | 2/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | HTR7 | P34969 | 1/20 | 0.34 |
| ▸ | FAAH | O00519 | 2/20 | 0.34 |
| ▸ | DRD3 | P35462 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14015609 | 0.95 | DRD2 (0.36) | KMT2AMEN1ALDH1A1IL6DRD2 | |
| SCHEMBL13639336 | 0.91 | HCRTR1 (0.37) | KMT2AALDH1A1IL6DRD2HTR1A | |
| SCHEMBL13639363 | 0.88 | KMT2A (0.38) | KMT2AMEN1ALDH1A1IL6DRD2 | |
| SCHEMBL14015597 | 0.88 | MAPT (0.48) | KMT2AMEN1ALDH1A1LMNAMAPT | |
| SCHEMBL13639362 | 0.88 | HTR1A (0.37) | ALDH1A1IL6DRD2HTR1AHTR7 | |
| SCHEMBL13639370 | 0.88 | IL6 (0.38) | KMT2AMEN1ALDH1A1IL6DRD2 | |
| SCHEMBL14015835 | 0.87 | IL6 (0.39) | ALDH1A1IL6DRD2HTR1AHTR7 | |
| SCHEMBL14015605 | 0.85 | KMT2A (0.36) | KMT2AALDH1A1IL6HTR1ALMNA | |
| SCHEMBL14878774 | 0.85 | ALOX15 (0.41) | KMT2AMEN1ALDH1A1IL6DRD2 | |
| SCHEMBL14015539 | 0.84 | IL6 (0.37) | KMT2AMEN1ALDH1A1IL6DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1995242-B1 | NOVEL 1,2,3,4-TETRAHYDROQUINOXALINE DERIVATIVE HAVING GLUCOCORTICOID RECEPTOR BINDING ACTIVITY | SANTEN PHARMACEUTICAL CO LTD (JP) | 2012-11-07 | — | — | EP | disclosed |
| EP-1995242-A1 | NOVEL 1,2,3,4-TETRAHYDROQUINOXALINE DERIVATIVE HAVING GLUCOCORTICOID RECEPTOR BINDING ACTIVITY | Santen Pharmaceutical Co., Ltd (JP) | 2008-11-26 | — | — | EP | disclosed |