Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 8/20 | 0.60 |
| ▸ | RAB9A | P51151 | 5/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | MMP13 | P45452 | 1/20 | 0.53 |
| ▸ | MLYCD | O95822 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14297354 | 0.85 | NPC1 (0.62) | NPC1RAB9ASMN1; SMN2LMNAPOLB | |
| SCHEMBL13655599 | 0.83 | NPC1 (0.55) | NPC1RAB9ASMN1; SMN2LMNAPOLB | |
| SCHEMBL11220601 | 0.82 | LMNA (0.85) | NPC1RAB9ASMN1; SMN2LMNAPOLB | |
| SCHEMBL18359001 | 0.81 | LMNA (0.62) | NPC1RAB9ASMN1; SMN2LMNAPOLB | |
| SCHEMBL17865780 | 0.78 | MLYCD (0.77) | NPC1RAB9ASMN1; SMN2LMNAPOLB | |
| SCHEMBL16144546 | 0.77 | LMNA (0.76) | NPC1RAB9ASMN1; SMN2LMNAPOLB | |
| SCHEMBL765958 | 0.77 | L3MBTL1 (0.74) | NPC1RAB9ASMN1; SMN2LMNAPOLB | |
| SCHEMBL9489979 | 0.77 | L3MBTL1 (0.86) | NPC1RAB9ASMN1; SMN2LMNAPOLB | |
| SCHEMBL764574 | 0.77 | MMP13 (0.81) | NPC1RAB9ASMN1; SMN2LMNAPOLB | |
| SCHEMBL16418403 | 0.76 | NPC1 (0.55) | NPC1RAB9ASMN1; SMN2LMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090252678-A1 | COX-2-TARGETED IMAGING AGENTS | VANDERBILT UNIVERSITY (US) | 2009-10-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090252678-A1 | COX-2-TARGETED IMAGING AGENTS | PTGS2, PTGES2, PTGER2 | NPC1 1041/4885RAB9A 4594/4885SMN1; SMN2 1325/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.