Sugi Predict

Sugi Predict / Compounds / SCHEMBL1365701

SCHEMBL1365701

SCHEMBL1365701

CC(=O)c1cccn1S(=O)(=O)c1ccccc1

nearest known ligand 0.51

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
▸ PKM P14618 1/20 0.51
▸ LMNA P02545 2/20 0.51
▸ SMN1; SMN2 Q16637 1/20 0.51
▸ PPME1 Q9Y570 3/20 0.47
▸ APEH P13798 1/20 0.46
▸ HTR6 P50406 5/20 0.45
▸ MEN1 O00255 3/20 0.45
▸ KMT2A Q03164 3/20 0.45
▸ ALDH1A1 P00352 1/20 0.45
▸ HPGD P15428 1/20 0.45
▸ TSHR P16473 1/20 0.45
▸ HTT P42858 1/20 0.45
▸ CYP2C19 P33261 2/20 0.43
▸ CYP3A4 P08684 1/20 0.42
▸ L3MBTL1 Q9Y468 1/20 0.42
▸ PLK1 P53350 1/20 0.41
▸ RAPGEF4 Q8WZA2 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14005234 0.87 RAPGEF4 (0.56) PKMALDH1A1HPGDHTTL3MBTL1
SCHEMBL27662268 0.86 PPME1 (0.49) PKMLMNASMN1; SMN2PPME1APEH
SCHEMBL17900455 0.86 PPME1 (0.49) PKMLMNASMN1; SMN2PPME1APEH
SCHEMBL15188900 0.85 PPME1 (0.46) PKMLMNASMN1; SMN2PPME1APEH
SCHEMBL26054592 0.82 PPME1 (0.46) PKMLMNASMN1; SMN2PPME1APEH
SCHEMBL17574711 0.82 MEN1 (0.55) PKMLMNASMN1; SMN2PPME1APEH
SCHEMBL8797471 0.80 PPME1 (0.42) PKMLMNASMN1; SMN2PPME1APEH
SCHEMBL8797600 0.79 PPME1 (0.43) PKMLMNASMN1; SMN2PPME1APEH
SCHEMBL4684791 0.79 SMN1; SMN2 (0.44) LMNASMN1; SMN2PPME1APEHMEN1
SCHEMBL2718306 0.79 LMNA (0.49) PKMLMNAPPME1APEHMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20100221647-A1 PYRROLE CONTAINING PHOTOCONDUCTORS XEROX CORPORATION (US) 2010-09-02 — — US claimed
US-9518051-B2 Pyrroloquinoline alkaloids as antimalarial agents and process for the preparation thereof COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) 2016-12-13 — — US disclosed
US-9518051-B2 Pyrroloquinoline alkaloids as antimalarial agents and process for the preparation thereof COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) 2016-12-13 — — US disclosed
US-20150336947-A1 PYRROLOQUINOLINE ALKALOIDS AS ANTIMALARIAL AGENTS AND PROCESS FOR THE PREPARATION THEREOF COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) 2015-11-26 — — US disclosed
US-20150336947-A1 PYRROLOQUINOLINE ALKALOIDS AS ANTIMALARIAL AGENTS AND PROCESS FOR THE PREPARATION THEREOF COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) 2015-11-26 — — US disclosed
WO-2013117986-A1 PYRROLOQUINOLINE ALKALOIDS AS ANTIMALARIAL AGENTS AND PROCESS FOR THE PREPARATION THEREOF COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) 2013-08-15 — — WO disclosed
US-8067138-B2 Pyrrole containing photoconductors XEROX CORPORATION (US) 2011-11-29 — — US disclosed
US-8067138-B2 Pyrrole containing photoconductors XEROX CORPORATION (US) 2011-11-29 — — US disclosed
US-8067138-B2 Pyrrole containing photoconductors XEROX CORPORATION (US) 2011-11-29 — — US disclosed
US-20100221647-A1 PYRROLE CONTAINING PHOTOCONDUCTORS XEROX CORPORATION (US) 2010-09-02 — — US disclosed
US-20070254881-A1 Pyrazole Derivative DAIICHI PHARMACEUTICAL CO., LTD. (JP) 2007-11-01 — — US disclosed
US-20070219210-A1 Amidopyrazole Derivative DAIICHI PHARMACEUTICAL CO., LTD. (JP) 2007-09-20 — — US disclosed
EP-1785418-A1 PYRAZOLE DERIVATIVE DAIICHI PHARMACEUTICAL CO., LTD. (JP) 2007-05-16 — — EP disclosed
EP-1698626-A1 AMIDOPYRAZOLE DERIVATIVE DAIICHI PHARMACEUTICAL CO., LTD. (JP) 2006-09-06 — — EP disclosed
US-20060128685-A1 Pyrazole derivative DAIICHI PHARMACEUTICAL CO., LTD., (JP) 2006-06-15 — — US disclosed
EP-1591443-A1 PYRAZOLE DERIVATIVE DAIICHI PHARMACEUTICAL CO., LTD. (JP) 2005-11-02 — — EP disclosed
US-6106599-A Inks XEROX CORPORATION (US) 2000-08-22 — — US disclosed
EP-0597291-B1 2,3-diphenyl-5-pyrrolyl-furan derivatives, processes and intermediates for their preparation and their use as anti-inflammatory, and anti-allergic and platelet aggregation inhibiting agents NIHON IYAKUHIN KOGYO CO LTD (JP) 1997-06-11 — — EP disclosed
US-5321041-A Antiallergens, antiinflammatory and anticaogulants NIHON IYAKUHIN KOGYO CO., LTD. (JP) 1994-06-14 — — US disclosed
EP-0597291-A1 2,3-diphenyl-5-pyrrolyl-furan derivatives, processes and intermediates for their preparation and their use as anti-inflammatory, and anti-allergic and platelet aggregation inhibiting agents NIHON IYAKUHIN KOGYO CO., LTD. (JP) 1994-05-18 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070254881-A1 Pyrazole Derivative PTGER1, PTGS1, PTGER2 PKM 1756/4885LMNA 4599/4885SMN1; SMN2 3490/4885
US-20060128685-A1 Pyrazole derivative PTGS1, PTGS2, PTGER1 PKM 1036/4885LMNA 4163/4885SMN1; SMN2 3778/4885
US-20070219210-A1 Amidopyrazole Derivative PTGER1, PTGS1, PTGER2 PKM 3096/4885LMNA 4352/4885SMN1; SMN2 4048/4885
US-20150336947-A1 PYRROLOQUINOLINE ALKALOIDS AS ANTIMALARIAL AGENTS AND PROCESS FOR THE PREPARATION THEREOF PLK1, POLQ, PTMA PKM 434/4885LMNA 697/4885SMN1; SMN2 2581/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.