Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPME1 | Q9Y570 | 3/20 | 0.46 |
| ▸ | APEH | P13798 | 1/20 | 0.43 |
| ▸ | HTR6 | P50406 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | PLK1 | P53350 | 1/20 | 0.39 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.38 |
| ▸ | MET | P08581 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26054490 | 0.88 | RAPGEF4 (0.52) | MEN1KMT2AALDH1A1HTTPKM | |
| SCHEMBL1365701 | 0.82 | PKM (0.51) | PPME1APEHHTR6LMNAMEN1 | |
| SCHEMBL17900455 | 0.82 | PPME1 (0.49) | PPME1APEHHTR6LMNAMEN1 | |
| SCHEMBL27662268 | 0.82 | PPME1 (0.49) | PPME1APEHHTR6LMNAMEN1 | |
| SCHEMBL17574711 | 0.78 | MEN1 (0.55) | PPME1APEHHTR6LMNAMEN1 | |
| SCHEMBL15188900 | 0.78 | PPME1 (0.46) | PPME1APEHHTR6LMNAMEN1 | |
| SCHEMBL8797471 | 0.76 | PPME1 (0.42) | PPME1APEHHTR6LMNAMEN1 | |
| SCHEMBL8797600 | 0.75 | PPME1 (0.43) | PPME1APEHHTR6LMNAMEN1 | |
| SCHEMBL4684791 | 0.75 | SMN1; SMN2 (0.44) | PPME1APEHLMNAMEN1KMT2A | |
| SCHEMBL2718306 | 0.75 | LMNA (0.49) | PPME1APEHLMNAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11731967-B2 | Inhibitors of TRIM33 and methods of use | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2023-08-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11731967-B2 | Inhibitors of TRIM33 and methods of use | TRIM33, TRIM28, TRIM4 | PPME1 176/4885APEH 4406/4885HTR6 4395/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.