Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | KEAP1 | Q14145 | 3/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | PLIN5 | Q00G26 | 1/20 | 0.35 |
| ▸ | ABHD5 | Q8WTS1 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | RPS6KA2 | Q15349 | 1/20 | 0.34 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13661980 | 0.86 | CYP1A2 (0.38) | ALDH1A1CYP1A2CYP2C9CYP2C19TP53 | |
| SCHEMBL13661982 | 0.79 | CYP1A2 (0.33) | ALDH1A1CYP1A2CYP2C9CYP2C19TP53 | |
| SCHEMBL13661981 | 0.79 | ALDH1A1 (0.33) | ALDH1A1CYP1A2CYP2C9CYP2C19TP53 | |
| SCHEMBL20479343 | 0.76 | KEAP1 (0.43) | ALDH1A1CYP1A2CYP2C9CYP2C19KEAP1 | |
| SCHEMBL3949971 | 0.76 | KEAP1 (0.43) | ALDH1A1CYP1A2CYP2C9CYP2C19KEAP1 | |
| SCHEMBL18342128 | 0.76 | KEAP1 (0.43) | ALDH1A1CYP1A2CYP2C9CYP2C19KEAP1 | |
| SCHEMBL13661907 | 0.76 | MMP2 (0.37) | ALDH1A1CYP2C9CYP2C19CA12CA9 | |
| SCHEMBL13661909 | 0.76 | CYP1A2 (0.34) | ALDH1A1CYP1A2CYP2C9CYP2C19TP53 | |
| SCHEMBL20783314 | 0.72 | SRC (0.40) | CYP1A2CYP2C19KEAP1 | |
| SCHEMBL3948769 | 0.72 | SRC (0.40) | CYP1A2CYP2C19KEAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090264431-A1 | NOVEL CATHEPSIN C INHIBITORS AND THEIR USE | GLAXO GROUP LIMITED (GB) | 2009-10-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090264431-A1 | NOVEL CATHEPSIN C INHIBITORS AND THEIR USE | CTSB, CTSS, CTSF | ALDH1A1 2060/4885CYP1A2 974/4885CYP2C9 1385/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.