Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.37 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | IAPP | P10997 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 4/20 | 0.34 |
| ▸ | RAB9A | P51151 | 4/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.33 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7926505 | 0.81 | GABRA1 (0.56) | ALDH1A1TSHRHMGB1GABRA1GABRB2 | |
| SCHEMBL1879310 | 0.81 | GABRA1 (0.43) | ALDH1A1HMGB1GABRA1GABRB2LMNA | |
| SCHEMBL7936755 | 0.76 | KDM4E (0.58) | ALDH1A1CYP3A4KDM4ENPC1RAB9A | |
| SCHEMBL3291708 | 0.75 | HMGB1 (0.62) | ALDH1A1TSHRHMGB1LMNAKDM4E | |
| SCHEMBL537039 | 0.74 | ALDH1A1 (0.49) | ALDH1A1TSHRHMGB1GABRA1GABRB2 | |
| SCHEMBL8731468 | 0.73 | ALDH1A1 (0.43) | ALDH1A1TSHRLMNACYP3A4KDM4E | |
| SCHEMBL20478154 | 0.73 | ALDH1A1 (0.47) | ALDH1A1TSHRHMGB1LMNACYP3A4 | |
| SCHEMBL20481943 | 0.73 | ALDH1A1 (0.47) | ALDH1A1TSHRHMGB1GABRA1GABRB2 | |
| SCHEMBL20482006 | 0.73 | ALDH1A1 (0.47) | ALDH1A1TSHRHMGB1GABRA1GABRB2 | |
| SCHEMBL2778 | 0.72 | TSHR (0.52) | ALDH1A1TSHRHMGB1LMNACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2331528-B1 | COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY DISORDERS | MERCK SHARP & DOHME (US) | 2020-05-27 | — | — | EP | disclosed |
| US-8859529-B2 | Compounds for the treatment of inflammatory disorders | MERCK SHARP & DOHME CORP. (US) | 2014-10-14 | — | — | US | disclosed |
| US-20110288054-A1 | COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY DISORDERS | SCHERING CORPORATION (US) | 2011-11-24 | — | — | US | disclosed |
| EP-2331528-A2 | COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY DISORDERS | Schering Corporation (US) | 2011-06-15 | — | — | EP | disclosed |
| WO-2010036638-A2 | COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY DISORDERS | SCHERING CORPORATION (US) | 2010-04-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110288054-A1 | COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY DISORDERS | ADAMTS1, ADAMTS13, ADAMTS7 | ALDH1A1 1223/4885TSHR 3544/4885HMGB1 91/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.