Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | KLK7 | P49862 | 1/20 | 0.46 |
| ▸ | APEX1 | P27695 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | MMP13 | P45452 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13680461 | 0.82 | SMN1; SMN2 (0.60) | TSHRKDM4EALDH1A1MEN1NPC1 | |
| SCHEMBL13680488 | 0.81 | KIF11 (0.59) | KDM4EALDH1A1MEN1NPC1GAA | |
| SCHEMBL13680486 | 0.79 | MAPT (0.52) | KDM4EALDH1A1MEN1NPC1GAA | |
| SCHEMBL13680510 | 0.79 | ALDH1A1 (0.52) | KDM4EALDH1A1MEN1NPC1GAA | |
| SCHEMBL687878 | 0.77 | TSHR (0.79) | TSHRMEN1KMT2ACA12CA1 | |
| SCHEMBL13680494 | 0.76 | ALDH1A1 (0.46) | KDM4EALDH1A1MEN1NPC1GAA | |
| SCHEMBL13680880 | 0.76 | TSHR (0.42) | TSHRKDM4EALDH1A1MEN1MAPT | |
| SCHEMBL13680490 | 0.75 | PSMB8 (0.54) | KDM4EALDH1A1MEN1NPC1GAA | |
| SCHEMBL13680705 | 0.74 | ALDH1A1 (0.48) | TSHRKDM4EALDH1A1MEN1NPC1 | |
| SCHEMBL4770587 | 0.74 | TSHR (0.68) | TSHRALDH1A1NPC1RAB9ACA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |