Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.66 |
| ▸ | HTT | P42858 | 1/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.66 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.66 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.58 |
| ▸ | CNR1 | P21554 | 1/20 | 0.57 |
| ▸ | CSF1R | P07333 | 1/20 | 0.56 |
| ▸ | FLT1 | P17948 | 1/20 | 0.56 |
| ▸ | FLT3 | P36888 | 1/20 | 0.56 |
| ▸ | IDO1 | P14902 | 1/20 | 0.54 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.53 |
| ▸ | MEN1 | O00255 | 5/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | HPGD | P15428 | 3/20 | 0.53 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13680541 | 0.88 | HSD17B10 (0.79) | HSD17B10SMN1; SMN2CNR1KMT2AMEN1 | |
| SCHEMBL8577619 | 0.86 | SMN1; SMN2 (0.70) | HSD17B10HTTSMN1; SMN2L3MBTL1CNR1 | |
| SCHEMBL13680497 | 0.85 | KIF11 (0.69) | CNR1CSF1RFLT1FLT3KMT2A | |
| SCHEMBL13680444 | 0.83 | CNR1 (0.62) | SMN1; SMN2CNR1CSF1RFLT1FLT3 | |
| SCHEMBL13680466 | 0.83 | FAAH (0.56) | SMN1; SMN2CNR1CSF1RFLT1FLT3 | |
| SCHEMBL12999591 | 0.83 | NPC1 (0.69) | HSD17B10HTTSMN1; SMN2L3MBTL1TDP1 | |
| SCHEMBL13680447 | 0.82 | PNPLA2 (0.62) | CNR1CSF1RFLT1FLT3KMT2A | |
| SCHEMBL23576901 | 0.81 | HTT (0.63) | HSD17B10HTTSMN1; SMN2L3MBTL1CNR1 | |
| SCHEMBL9293265 | 0.81 | IDO1 (0.64) | HSD17B10HTTSMN1; SMN2L3MBTL1IDO1 | |
| SCHEMBL17316953 | 0.81 | HTT (0.63) | HSD17B10HTTSMN1; SMN2L3MBTL1CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |
| WO-2006069788-A1 | ORGANIC COMPOUNDS | NOVARTIS AG (CH) | 2006-07-06 | — | — | WO | disclosed |