Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.34 |
| ▸ | IDH1 | O75874 | 3/20 | 0.33 |
| ▸ | IDH2 | P48735 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.33 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.32 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.32 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.31 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.31 |
| ▸ | PLA2G5 | P39877 | 1/20 | 0.31 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.30 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.30 |
| ▸ | HTR1A | P08908 | 1/20 | 0.30 |
| ▸ | DRD2 | P14416 | 1/20 | 0.30 |
| ▸ | DRD4 | P21917 | 1/20 | 0.30 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13680845 | 0.80 | SCN9A (0.41) | TRPV3 | |
| SCHEMBL13680832 | 0.79 | KDM1A (0.40) | KCNH2 | |
| SCHEMBL13680824 | 0.77 | SUCNR1 (0.44) | TRPV3 | |
| SCHEMBL8648745 | 0.76 | P2RX7 (0.41) | IDH1IDH2HCRTR1HCRTR2KCNH2 | |
| SCHEMBL30583867 | 0.75 | TRPV3 (0.38) | TRPV3IDH1IDH2HCRTR1HCRTR2 | |
| SCHEMBL21849249 | 0.75 | TRPV3 (0.38) | TRPV3IDH1IDH2HCRTR1HCRTR2 | |
| SCHEMBL13680814 | 0.73 | KCNH2 (0.35) | KCNH2 | |
| SCHEMBL22493897 | 0.73 | TRPV3 (0.38) | TRPV3IDH1IDH2HCRTR1HCRTR2 | |
| SCHEMBL25236473 | 0.71 | TERT (0.39) | IDH1IDH2CHRM2CHRM1CHRM3 | |
| SCHEMBL1463893 | 0.69 | PARP1 (0.36) | HTR1ADRD2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |