Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 7/20 | 0.43 |
| ▸ | LMNA | P02545 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 7/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13680957 | 0.87 | KDM4E (0.50) | KDM4EALDH1A1HPGDRAB9AMAPT | |
| SCHEMBL13680942 | 0.84 | KDM4E (0.47) | KDM4EALDH1A1HPGDRAB9AMAPT | |
| SCHEMBL13680939 | 0.84 | MAPT (0.47) | KDM4EALDH1A1HPGDRAB9AMAPT | |
| SCHEMBL13680946 | 0.82 | AVPR1B (0.47) | KDM4EALDH1A1HPGDRAB9AMAPT | |
| SCHEMBL13680929 | 0.81 | ALDH1A1 (0.62) | KDM4EALDH1A1HPGDRAB9AMAPT | |
| SCHEMBL13680940 | 0.79 | TP53 (0.45) | RAB9AMAPTLMNASMN1; SMN2TP53 | |
| SCHEMBL13681038 | 0.79 | MAPT (0.41) | KDM4EALDH1A1HPGDRAB9AMAPT | |
| SCHEMBL13680988 | 0.78 | MAPT (0.44) | KDM4EALDH1A1HPGDRAB9AMAPT | |
| SCHEMBL13680932 | 0.78 | KMT2A (0.47) | KDM4EALDH1A1HPGDRAB9AMAPT | |
| SCHEMBL13680842 | 0.78 | RAB9A (0.45) | KDM4EALDH1A1HPGDRAB9AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |