Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | PKM | P14618 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.43 |
| ▸ | RELA | Q04206 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 8/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13680840 | 0.88 | RAB9A (0.41) | RAB9AALDH1A1NPC1SMN1; SMN2PKM | |
| SCHEMBL13680838 | 0.84 | SCN9A (0.42) | RAB9ANPC1SMN1; SMN2MAPTNFKB1 | |
| SCHEMBL13680839 | 0.83 | ALDH1A1 (0.45) | RAB9AALDH1A1NPC1SMN1; SMN2PKM | |
| SCHEMBL13681339 | 0.82 | SCN9A (0.38) | RAB9ANPC1SMN1; SMN2MAPTNFKB1 | |
| SCHEMBL13680837 | 0.81 | ALDH1A1 (0.40) | ALDH1A1KDM4EHPGDTSHRKMT2A | |
| SCHEMBL13680815 | 0.81 | PDE10A (0.46) | RAB9AALDH1A1NPC1SMN1; SMN2KDM4E | |
| SCHEMBL13680841 | 0.79 | TSHR (0.40) | KDM4ETSHRKMT2AGAA | |
| SCHEMBL13680825 | 0.78 | MAPT (0.41) | ALDH1A1SMN1; SMN2MAPTHPGDKMT2A | |
| SCHEMBL13680831 | 0.78 | PDE10A (0.37) | SMN1; SMN2MAPT | |
| SCHEMBL13680941 | 0.78 | KDM4E (0.47) | RAB9AALDH1A1NPC1SMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |