Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 6/20 | 0.43 |
| ▸ | LMNA | P02545 | 6/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 8/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13680957 | 0.88 | KDM4E (0.50) | KDM4EALDH1A1HPGDMAPTLMNA | |
| SCHEMBL13680941 | 0.84 | KDM4E (0.47) | KDM4EALDH1A1HPGDMAPTLMNA | |
| SCHEMBL13680939 | 0.84 | MAPT (0.47) | KDM4EALDH1A1HPGDMAPTLMNA | |
| SCHEMBL13680945 | 0.83 | MEN1 (0.52) | KDM4EALDH1A1HPGDMAPTLMNA | |
| SCHEMBL13680929 | 0.82 | ALDH1A1 (0.62) | KDM4EALDH1A1HPGDMAPTLMNA | |
| SCHEMBL13680938 | 0.80 | MEN1 (0.49) | KDM4EMAPTLMNATP53HTT | |
| SCHEMBL13680943 | 0.80 | RAB9A (0.48) | KDM4EALDH1A1HPGDMAPTLMNA | |
| SCHEMBL13681044 | 0.80 | MAPT (0.41) | KDM4EALDH1A1HPGDMAPTLMNA | |
| SCHEMBL13680937 | 0.79 | KDM4E (0.52) | KDM4EALDH1A1HPGDMAPTLMNA | |
| SCHEMBL13680931 | 0.79 | SHMT2 (0.56) | KDM4EALDH1A1HPGDMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |