Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.39 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.39 |
| ▸ | CCNC | P24863 | 4/20 | 0.38 |
| ▸ | CDK8 | P49336 | 4/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | AR | P10275 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | APP | P05067 | 1/20 | 0.36 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | FAAH | O00519 | 1/20 | 0.35 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13680855 | 0.78 | IRAK4 (0.42) | TRPA1IRAK4CCNCCDK8AR | |
| SCHEMBL13680907 | 0.76 | APP (0.42) | TRPA1CCNCCDK8ARAPP | |
| SCHEMBL13680618 | 0.76 | TRPA1 (0.46) | TRPA1IRAK4CCNCCDK8AR | |
| SCHEMBL13680926 | 0.74 | LMNA (0.56) | LMNASMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL13680981 | 0.74 | GSK3B (0.46) | TRPA1CDK8 | |
| SCHEMBL13681062 | 0.73 | LMNA (0.44) | LMNASMN1; SMN2L3MBTL1KDM4ERXFP1 | |
| SCHEMBL13680955 | 0.73 | GAA (0.42) | LMNASMN1; SMN2KDM4EALDH1A1HPGD | |
| SCHEMBL13680986 | 0.72 | GUSB (0.45) | ENPP2 | |
| SCHEMBL13681055 | 0.72 | KDM4E (0.46) | LMNASMN1; SMN2KDM4EALDH1A1HPGD | |
| SCHEMBL13680922 | 0.72 | GFER (0.62) | LMNASMN1; SMN2KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |