Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 7/20 | 0.42 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.42 |
| ▸ | TGFBR1 | P36897 | 7/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 6/20 | 0.39 |
| ▸ | CCNC | P24863 | 2/20 | 0.39 |
| ▸ | CDK8 | P49336 | 2/20 | 0.39 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | AR | P10275 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13680984 | 0.78 | LMNA (0.39) | IRAK4TRPA1CCNCCDK8CREBBP | |
| SCHEMBL13680555 | 0.75 | TGFBR1 (0.55) | IRAK4TRPA1TGFBR1MAPK14 | |
| SCHEMBL13680907 | 0.75 | APP (0.42) | TRPA1CCNCCDK8CREBBPBRD4 | |
| SCHEMBL15332767 | 0.74 | TRPA1 (0.49) | TRPA1TGFBR1MAPK14CREBBPBRD4 | |
| SCHEMBL17547051 | 0.74 | TRPA1 (0.49) | TRPA1TGFBR1MAPK14CCNCCDK8 | |
| SCHEMBL13680834 | 0.74 | PDE10A (0.39) | IRAK4 | |
| SCHEMBL13680847 | 0.73 | PDE10A (0.43) | IRAK4 | |
| SCHEMBL13680817 | 0.73 | ALDH1A1 (0.47) | — | |
| SCHEMBL15341838 | 0.72 | TRPA1 (0.47) | IRAK4TRPA1 | |
| SCHEMBL3854280 | 0.72 | MEN1 (0.50) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |