Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 17/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | LOXL3 | P58215 | 1/20 | 0.39 |
| ▸ | LOX | P28300 | 2/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.33 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13680728 | 0.78 | ALDH1A1 (0.53) | ALDH1A1POLBMAPTTHRBHTT | |
| SCHEMBL13680727 | 0.73 | LMNA (0.42) | ALDH1A1POLBMAPTTHRBHTT | |
| SCHEMBL13680724 | 0.72 | DYRK1A (0.43) | ALDH1A1POLBMAPTTHRBHTT | |
| SCHEMBL13680729 | 0.72 | APAF1 (0.34) | ALDH1A1POLBMAPTTHRBHTT | |
| SCHEMBL14854115 | 0.68 | TDP1 (0.48) | ALDH1A1POLBMAPTTHRBHTT | |
| SCHEMBL14750526 | 0.67 | TDP1 (0.42) | ALDH1A1MAPTHSD17B10TDP1ADORA2A | |
| SCHEMBL21812622 | 0.67 | LOXL2 (0.84) | LOXL2LOXL3MAOA | |
| SCHEMBL13681329 | 0.67 | LOXL2 (0.70) | LOXL2ALDH1A1LOXL3LOXMAOA | |
| SCHEMBL13681316 | 0.67 | LOXL2 (0.50) | LOXL2LOXL3LOXMAOAMAOB | |
| SCHEMBL1366842 | 0.67 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |