Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 10/20 | 0.40 |
| ▸ | RAB9A | P51151 | 10/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13680728 | 0.77 | ALDH1A1 (0.53) | NPC1RAB9ASMN1; SMN2TP53ALDH1A1 | |
| SCHEMBL13680724 | 0.75 | DYRK1A (0.43) | LMNANPC1RAB9ASMN1; SMN2TP53 | |
| SCHEMBL13680729 | 0.75 | APAF1 (0.34) | LMNANPC1RAB9ASMN1; SMN2PKM | |
| SCHEMBL13681340 | 0.73 | LOXL2 (0.44) | ALDH1A1MAPTHTTL3MBTL1TDP1 | |
| SCHEMBL13681033 | 0.72 | LMNA (0.38) | LMNANPC1RAB9ASMN1; SMN2PKM | |
| SCHEMBL14854115 | 0.71 | TDP1 (0.48) | LMNANPC1RAB9ASMN1; SMN2PKM | |
| SCHEMBL14750526 | 0.70 | TDP1 (0.42) | LMNANPC1RAB9ASMN1; SMN2PKM | |
| SCHEMBL13513650 | 0.69 | KDR (0.66) | LMNANPC1RAB9AMAPTCYP1A2 | |
| SCHEMBL13680700 | 0.68 | MAP4K4 (0.41) | LMNANPC1RAB9ASMN1; SMN2PKM | |
| SCHEMBL20182414 | 0.67 | ALDH1A1 (0.42) | LMNANPC1RAB9ASMN1; SMN2PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |