Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | THRB | P10828 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | RECQL | P46063 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | BACE1 | P56817 | 1/20 | 0.45 |
| ▸ | NOS1 | P29475 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 7/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 7/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13681340 | 0.78 | LOXL2 (0.44) | ALDH1A1MAPTTDP1POLBTHRB | |
| SCHEMBL13680727 | 0.77 | LMNA (0.42) | ALDH1A1MAPTTDP1POLBTHRB | |
| SCHEMBL13680729 | 0.76 | APAF1 (0.34) | ALDH1A1MAPTTDP1POLBTHRB | |
| SCHEMBL13680724 | 0.76 | DYRK1A (0.43) | ALDH1A1MAPTTDP1POLBTHRB | |
| SCHEMBL14854115 | 0.72 | TDP1 (0.48) | ALDH1A1MAPTTDP1POLBTHRB | |
| SCHEMBL14750526 | 0.71 | TDP1 (0.42) | ALDH1A1MAPTTDP1HSD17B10SMN1; SMN2 | |
| SCHEMBL21242477 | 0.71 | NOS1 (0.55) | ALDH1A1MAPTTDP1POLBTHRB | |
| SCHEMBL11364130 | 0.69 | ALDH1A1 (0.51) | ALDH1A1MAPTTDP1POLBTHRB | |
| SCHEMBL15173248 | 0.69 | ALDH1A1 (0.51) | ALDH1A1MAPTTDP1POLBTHRB | |
| SCHEMBL16061820 | 0.69 | ALDH1A1 (1.00) | ALDH1A1MAPTTDP1POLBTHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |