Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APAF1 | O14727 | 1/20 | 0.34 |
| ▸ | G6PD | P11413 | 1/20 | 0.34 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.34 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.32 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.32 |
| ▸ | NPC1 | O15118 | 3/20 | 0.31 |
| ▸ | RAB9A | P51151 | 3/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13680728 | 0.76 | ALDH1A1 (0.53) | ALDH1A1TDP1HSD17B10MAPTPOLB | |
| SCHEMBL14558238 | 0.75 | APAF1 (0.43) | APAF1G6PDMCL1ESR2ALDH1A1 | |
| SCHEMBL13680727 | 0.75 | LMNA (0.42) | ALDH1A1TDP1HSD17B10MAPTPOLB | |
| SCHEMBL13680724 | 0.73 | DYRK1A (0.43) | ALDH1A1TDP1HSD17B10MAPTPOLB | |
| SCHEMBL13681037 | 0.73 | APAF1 (0.31) | APAF1G6PDMCL1ESR2ALDH1A1 | |
| SCHEMBL13681340 | 0.72 | LOXL2 (0.44) | ALDH1A1TDP1HSD17B10MAPTPOLB | |
| SCHEMBL2406268 | 0.70 | HDAC1 (0.40) | APAF1G6PDMCL1ESR2ALDH1A1 | |
| SCHEMBL14854115 | 0.69 | TDP1 (0.48) | ALDH1A1TDP1HSD17B10MAPTPOLB | |
| SCHEMBL14750526 | 0.69 | TDP1 (0.42) | ALDH1A1TDP1HSD17B10MAPTADORA2A | |
| SCHEMBL980817 | 0.68 | HTR7 (0.50) | ALDH1A1MAPTPOLBLMNAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |