Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 6/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.41 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.41 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.41 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10015691 | 0.81 | ALDH1A1 (0.80) | ALDH1A1LMNAKMT2AHPGDTSHR | |
| SCHEMBL13544566 | 0.79 | SMN1; SMN2 (0.65) | ALDH1A1LMNAKMT2AHPGDSMN1; SMN2 | |
| SCHEMBL27892099 | 0.79 | SMN1; SMN2 (0.72) | ALDH1A1LMNAKMT2AHPGDTSHR | |
| SCHEMBL4455867 | 0.78 | SMN1; SMN2 (0.69) | ALDH1A1LMNAKMT2AHPGDTSHR | |
| SCHEMBL13708632 | 0.78 | SMN1; SMN2 (0.69) | ALDH1A1LMNAKMT2AHPGDTSHR | |
| SCHEMBL10132085 | 0.76 | SMN1; SMN2 (0.65) | ALDH1A1LMNAKMT2AHPGDTSHR | |
| SCHEMBL23080295 | 0.76 | SMN1; SMN2 (0.50) | ALDH1A1LMNAKMT2AHPGDTSHR | |
| SCHEMBL9516460 | 0.74 | ALDH1A1 (0.69) | ALDH1A1LMNAKMT2AHPGDTSHR | |
| SCHEMBL18536761 | 0.74 | ALDH1A1 (0.88) | ALDH1A1KMT2AHPGDTSHRSMN1; SMN2 | |
| E388 SCHEMBL28696 | 0.73 | LMNA (1.00) | ALDH1A1LMNAKMT2AHSD17B10TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1931327-B1 | CYCLOPROPYL COMPOUNDS AND COMPOSITIONS FOR DELIVERING ACTIVE AGENTS | EMISPHERE TECH INC (US) | 2016-08-17 | — | — | EP | disclosed |
| US-8541362-B2 | Cyclopropyl compounds and compositions for delivering active agents | EMISPHERE TECHNOLOGIES, INC. (US) | 2013-09-24 | — | — | US | disclosed |
| US-8541362-B2 | Cyclopropyl compounds and compositions for delivering active agents | EMISPHERE TECHNOLOGIES, INC. (US) | 2013-09-24 | — | — | US | disclosed |
| US-20090220451-A1 | CYCLOPROPYL COMPOUNDS AND COMPOSITIONS FOR DELIVERING ACTIVE AGENTS | EMISPHERE TECHNOLOGIES, INC. (US) | 2009-09-03 | — | — | US | disclosed |
| US-20090220451-A1 | CYCLOPROPYL COMPOUNDS AND COMPOSITIONS FOR DELIVERING ACTIVE AGENTS | EMISPHERE TECHNOLOGIES, INC. (US) | 2009-09-03 | — | — | US | disclosed |
| WO-2007022532-A2 | CYCLOPROPYL COMPOUNDS AND COMPOSITIONS FOR DELIVERING ACTIVE AGENTS | EMISPHERE TECHNOLOGIES, INC. (US) | 2007-02-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090220451-A1 | CYCLOPROPYL COMPOUNDS AND COMPOSITIONS FOR DELIVERING ACTIVE AGENTS | PAICS, ABCB4, ABCB11 | ALDH1A1 2599/4885LMNA 367/4885KMT2A 4678/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.