Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | LTA4H | P09960 | 6/20 | 0.51 |
| ▸ | RAB9A | P51151 | 4/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | NOX1 | Q9Y5S8 | 2/20 | 0.44 |
| ▸ | RORC | P51449 | 1/20 | 0.44 |
| ▸ | AR | P10275 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3635901 | 0.86 | LTA4H (0.56) | LMNAPOLBMAPTHTTLTA4H | |
| SCHEMBL6717933 | 0.86 | LTA4H (0.58) | LMNAPOLBMAPTHTTLTA4H | |
| SCHEMBL8302564 | 0.79 | MEN1 (0.51) | LMNAMAPTLTA4HRAB9ASMN1; SMN2 | |
| SCHEMBL8542598 | 0.75 | L3MBTL1 (0.41) | LMNAALDH1A1CA12CA1 | |
| SCHEMBL3823095 | 0.74 | LTA4H (0.62) | LMNAPOLBMAPTHTTLTA4H | |
| SCHEMBL25604063 | 0.73 | HSD17B10 (0.48) | MAPTRAB9ASMN1; SMN2NPC1ALDH1A1 | |
| SCHEMBL2987817 | 0.73 | RAB9A (0.74) | LTA4HRAB9ASMN1; SMN2NPC1ALDH1A1 | |
| SCHEMBL7468687 | 0.72 | ALDH1A1 (0.53) | LMNAMAPTLTA4HRAB9ASMN1; SMN2 | |
| SCHEMBL3017819 | 0.72 | LTA4H (0.68) | LMNAPOLBMAPTHTTLTA4H | |
| SCHEMBL7857951 | 0.71 | PSMB5 (0.46) | LMNAPOLBMAPTHTTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1904484-B1 | COMPOUNDS | GLAXO GROUP LTD (GB) | 2009-08-26 | — | — | EP | disclosed |
| US-20080275027-A1 | Piperazinone Derivatives Useful as Histamine H3 Receptor Antagonists and/or Inverse Agonists | GLAXO GROUP LIMITED (GB) | 2008-11-06 | — | — | US | disclosed |
| US-20080275027-A1 | Piperazinone Derivatives Useful as Histamine H3 Receptor Antagonists and/or Inverse Agonists | GLAXO GROUP LIMITED (GB) | 2008-11-06 | — | — | US | disclosed |
| US-20080207638-A1 | Compounds | GLAXOSMITHKLINE ISTRAZIVACKI CENTER ZAGREB D.O.O (GB) | 2008-08-28 | — | — | US | disclosed |
| US-20080207638-A1 | Compounds | GLAXOSMITHKLINE ISTRAZIVACKI CENTER ZAGREB D.O.O (GB) | 2008-08-28 | — | — | US | disclosed |
| WO-2007009739-A1 | COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2007-01-25 | — | — | WO | disclosed |
| WO-2007009741-A1 | PIPERAZINONE DERIVATIVES USEFUL AS HISTAMINE H3 RECEPTOR ANTAGONISTS AND/OR INVERSE AGONISTS | GLAXO GROUP LIMITED (GB) | 2007-01-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080207638-A1 | Compounds | CMA1, MRGPRX2, HRH2 | LMNA 2529/4885POLB 3167/4885MAPT 1387/4885 |
| US-20080275027-A1 | Piperazinone Derivatives Useful as Histamine H3 Receptor Antagonists and/or Inverse Agonists | HRH3, HRH1, HRH4 | LMNA 3821/4885POLB 2494/4885MAPT 2812/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.