SCHEMBL1375362

SCHEMBL1375362

Cc1ccc(C(=O)Cl)cc1C(=O)Cl

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC8 Q9BY41 2/20 0.41
HDAC1 Q13547 2/20 0.41
HDAC6 Q9UBN7 2/20 0.41
MAPT P10636 1/20 0.41
TDP1 Q9NUW8 1/20 0.41
CES2 O00748 2/20 0.38
CES1 P23141 2/20 0.38
HTT P42858 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.38
ALDH1A1 P00352 5/20 0.38
TSHR P16473 2/20 0.36
HPGD P15428 1/20 0.36
MEN1 O00255 1/20 0.35
KMT2A Q03164 1/20 0.35
KCNQ3 O43525 1/20 0.35
KCNQ2 O43526 1/20 0.35
LMNA P02545 2/20 0.34
ALOX15 P16050 1/20 0.34
CYP2A6 P11509 1/20 0.34
HSD17B1 P14061 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31634804 0.84 CES2 (0.39) MAPTTDP1CES2CES1HTT
SCHEMBL1773780 0.84 CES2 (0.39) MAPTTDP1CES2CES1HTT
SCHEMBL40769 0.82 SMN1; SMN2 (0.55) MAPTTDP1CES2CES1HTT
SCHEMBL30475402 0.82 SMN1; SMN2 (0.55) MAPTTDP1CES2CES1HTT
SCHEMBL8756315 0.81 ALDH1A1 (0.50) TDP1CES2CES1ALDH1A1HPGD
SCHEMBL2154184 0.81 ALDH1A1 (0.37) MAPTTDP1CES2CES1HTT
SCHEMBL9153003 0.80 MCL1 (0.48) TDP1ALDH1A1TSHRMEN1KMT2A
SCHEMBL1311663 0.80 MEN1 (0.53) MAPTHTTSMN1; SMN2ALDH1A1TSHR
SCHEMBL75886 0.79 ALDH1A1 (0.40) MAPTTDP1CES2CES1HTT
SCHEMBL29440655 0.79 ALDH1A1 (0.40) MAPTTDP1CES2CES1HTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9882136-B2 Organic electroluminescent device HODOGAYA CHEMICAL CO., LTD. (JP) 2018-01-30 US disclosed
EP-2858458-B1 ORGANIC ELECTROLUMINESCENT ELEMENT HODOGAYA CHEMICAL CO LTD (JP) 2017-05-31 EP disclosed
US-20150287920-A1 ORGANIC ELECTROLUMINESCENT DEVICE HODOGAYA CHEMICAL CO., LTD. (JP) 2015-10-08 US disclosed
EP-2858458-A1 ORGANIC ELECTROLUMINESCENT ELEMENT Hodogaya Chemical Co., Ltd. (JP) 2015-04-08 EP disclosed
US-20110288258-A1 CROSSLINKED POLYAMIDE BASF SE (DE) 2011-11-24 US disclosed
EP-0348825-A2 High molecular weight poly-(toluenediamine aramides) and a method for their preparation AIR PRODUCTS AND CHEMICALS, INC. (US) 1990-01-03 EP disclosed
US-4885356-A HIGH STRENGTH, TOUGHNESS AIR PRODUCTS AND CHEMICALS, INC. (US) 1989-12-05 US disclosed
US-4113683-A Production of high temperature resistant polymer compositions capable of forming superior fiber reinforced composite articles CELANESE CORPORATION (US) 1978-09-12 US disclosed
US-4009154-A Process for preparing aromatic polyamides with sodium carbonate hydrate as acid acceptor TEIJIN LIMITED (JA) 1977-02-22 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150287920-A1 ORGANIC ELECTROLUMINESCENT DEVICE CDH1, STRA6, SLC39A7 HDAC8 4291/4885HDAC1 2270/4885HDAC6 3560/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.