SCHEMBL1376918

SCHEMBL1376918

C=CS(=O)(=O)c1cccc([NH])c1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 3/20 0.42
ALDH1A1 P00352 2/20 0.42
HSD17B10 Q99714 2/20 0.42
LMNA P02545 2/20 0.42
SMN1; SMN2 Q16637 2/20 0.42
NPC1 O15118 1/20 0.42
TP53 P04637 1/20 0.42
MAPT P10636 1/20 0.42
XBP1 P17861 1/20 0.42
MAPK1 P28482 1/20 0.42
HTT P42858 1/20 0.42
RAB9A P51151 1/20 0.42
MDM2 Q00987 1/20 0.42
CA1 P00915 2/20 0.35
CA2 P00918 2/20 0.35
BTK Q06187 1/20 0.35
TDP1 Q9NUW8 2/20 0.34
TLR9 Q9NR96 1/20 0.33
EPAS1 Q99814 1/20 0.32
NFE2L2 Q16236 6/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL54845 0.85 TSHR (0.50) TSHRALDH1A1HSD17B10LMNASMN1; SMN2
SCHEMBL156542 0.77 ALDH1A1 (0.57) TSHRALDH1A1HSD17B10LMNASMN1; SMN2
SCHEMBL1376919 0.76 ALDH1A1 (0.62) TSHRALDH1A1HSD17B10LMNASMN1; SMN2
SCHEMBL13214022 0.76 KMT2A (0.50) TSHRALDH1A1HSD17B10LMNASMN1; SMN2
SCHEMBL7650936 0.76 HSD17B1 (0.42) TSHRALDH1A1HSD17B10LMNASMN1; SMN2
SCHEMBL30084596 0.76 NFE2L2 (0.53) TSHRALDH1A1HSD17B10LMNASMN1; SMN2
SCHEMBL9695867 0.74 PFKFB3 (0.45) TSHRALDH1A1HSD17B10LMNASMN1; SMN2
SCHEMBL8658955 0.74 CA1 (0.45) TSHRALDH1A1HSD17B10LMNASMN1; SMN2
SCHEMBL1374723 0.74 ALDH1A1 (0.59) TSHRALDH1A1HSD17B10LMNASMN1; SMN2
(Ethenylsulfonyl)Benzene SCHEMBL1331367 0.73 TLR9 (0.58) TSHRALDH1A1HSD17B10LMNASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 76 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1490441-B2 DYE MIXTURES OF FIBER-REACTIVE AZO DYES, THEIR PRODUCTION AND USE DYSTAR COLOURS DISTRIB GMBH (DE) 2012-12-26 EP claimed
US-20090320217-A1 MIXTURES OF FIBRE-REACTIVE AZO DYES DYSTAR TEXTIFARBEN GMBH & CO. DEUTSCHLAND KG (DE) 2009-12-31 US claimed
EP-2118214-A2 MIXTURES OF FIBRE-REACTIVE AZO DYES DyStar Textilfarben GmbH & Co. Deutschland KG (DE) 2009-11-18 EP claimed
US-20090025152-A1 DYE MIXTURES OF FIBER-REACTIVE AZO DYES, THEIR PREPARATION AND USE DYSTAR TEXTILFARBEN GMBH & CO. DEUTSCHLAND KG (DE) 2009-01-29 US claimed
EP-1508596-B1 Mixtures of azo reactive dyes, process for their preparation and the use thereof DYSTAR TEXTILFARBEN GMBH & CO (DE) 2009-01-28 EP claimed
EP-1490441-B1 DYE MIXTURES OF FIBER-REACTIVE AZO DYES, THEIR PRODUCTION AND USE DYSTAR TEXTILFARBEN GMBH & CO (DE) 2008-09-10 EP claimed
WO-2008095802-A2 MIXTURES OF FIBRE-REACTIVE AZO DYES DYSTAR TEXTILFARBEN GMBH & CO. DEUTSCHLAND KG (DE) 2008-08-14 WO claimed
EP-1490442-B1 DYE MIXTURES OF FIBRE REACTIVE AZODYES, PRODUCTION AND USE THEREOF DYSTAR TEXTILFARBEN GMBH & CO (DE) 2008-03-19 EP claimed
EP-1508598-B1 Mixture of fiberreactive azo dyes process for their preparation and use DYSTAR TEXTILFARBEN GMBH & CO (DE) 2008-03-19 EP claimed
US-7132515-B2 Fiber-reactive AZO dyes, preparation thereof and use thereof DYSTAR TEXTILFARBEN GMBH & CO. DEUTSCHLAND KG (DE) 2006-11-07 US claimed
US-20050166339-A1 Dye mixtures of fiber-reactive azo dyes, their preparation and use DYSTAR TEXTILFARBEN GMBH & CO.DEUTSCHLAND KG (DE) 2005-08-04 US claimed
US-20050150063-A1 Fiber-reactive azo dyes, preparation thereof and use thereof DYSTAR TEXTILFARBEN GMBH & CO. DEUTSCHLAND KG (DE) 2005-07-14 US claimed
EP-1508596-A1 Mixtures of azo reactive dyes, process for their preparation and the use thereof DyStar Textilfarben GmbH & Co. Deutschland KG (DE) 2005-02-23 EP claimed
EP-1508598-A1 Mixture of fiberreactive azo dyes process for their preparation and use DyStar Textilfarben GmbH & Co. Deutschland KG (DE) 2005-02-23 EP claimed
US-20050034252-A1 Dye mixtures of fiber-reactive azo dyes, their preparation and their use DYSTAR TEXTILFARBEN GMBH & CO. (DE) 2005-02-17 US claimed
US-20050034253-A1 Mixture; ink for ink jet printing DYSTAR TEXTILFARBEN GMBH & CO. DEUTSCHLAND KG (DE) 2005-02-17 US claimed
EP-1499681-A1 FIBRE-REACTIVE AZO DYES, THEIR PRODUCTION AND THEIR USE DyStar Textilfarben GmbH & Co. Deutschland KG (DE) 2005-01-26 EP claimed
EP-1490442-A1 DYE MIXTURES OF FIBRE REACTIVE AZODYES, PRODUCTION AND USE THEREOF DyStar Textilfarben GmbH & Co. Deutschland KG (DE) 2004-12-29 EP claimed
WO-2003089521-A1 FIBRE-REACTIVE AZO DYES, THEIR PRODUCTION AND THEIR USE DYSTAR TEXTILFARBEN GMBH & CO. DEUTSCHLAND KG (DE) 2003-10-30 WO claimed
WO-2003080741-A1 DYE MIXTURES OF FIBRE REACTIVE AZODYES, PRODUCTION AND USE THEREOF DYSTAR TEXTILFARBEN GMBH & CO. DEUTSCHLAND KG (DE) 2003-10-02 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050034252-A1 Dye mixtures of fiber-reactive azo dyes, their preparation and their use CRY1, FZD7, CBR3 TSHR 2434/4885ALDH1A1 617/4885HSD17B10 2946/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.