SCHEMBL1377763

SCHEMBL1377763

O=P(OCl)(OCl)Oc1ccccc1Cl

nearest known ligand 0.62

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 0.62
SMN1; SMN2 Q16637 1/20 0.62
MAPK1 P28482 1/20 0.44
PKM P14618 2/20 0.43
POLB P06746 1/20 0.43
GAA P10253 1/20 0.43
L3MBTL1 Q9Y468 1/20 0.42
PTK2B Q14289 1/20 0.40
HPGD P15428 3/20 0.38
TSHR P16473 2/20 0.37
MEN1 O00255 1/20 0.36
KMT2A Q03164 1/20 0.36
CXCL8 P10145 1/20 0.36
RAB9A P51151 1/20 0.36
HDAC6 Q9UBN7 1/20 0.35
RXRA P19793 1/20 0.34
RXRB P28702 1/20 0.34
TP53 P04637 1/20 0.34
HTT P42858 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3238689 0.96 LMNA (0.62) LMNASMN1; SMN2MAPK1PKMPOLB
SCHEMBL2035293 0.89 LMNA (0.69) LMNASMN1; SMN2MAPK1PKMPOLB
SCHEMBL28790808 0.89 LMNA (0.59) LMNASMN1; SMN2MAPK1PKMPOLB
SCHEMBL9493715 0.85 LMNA (0.64) LMNASMN1; SMN2MAPK1PKMPOLB
SCHEMBL28458158 0.84 SMN1; SMN2 (0.44) LMNASMN1; SMN2MAPK1POLBGAA
SCHEMBL5850556 0.82 LMNA (0.47) LMNASMN1; SMN2MAPK1PKMPOLB
SCHEMBL27626350 0.82 LMNA (0.60) LMNASMN1; SMN2MAPK1PKMPOLB
SCHEMBL3222697 0.82 LMNA (0.60) LMNASMN1; SMN2MAPK1PKMPOLB
SCHEMBL28399641 0.81 LMNA (0.46) LMNASMN1; SMN2MAPK1PKMPOLB
SCHEMBL2980601 0.80 LMNA (0.58) LMNASMN1; SMN2MAPK1PKMPOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 165 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20170210775-A1 GUGGULPHOSPHOLIPID METHODS AND COMPOSITIONS JINA PHARMACEUTICALS, INC. 2017-07-27 US claimed
US-9637515-B2 Guggulphospholipid methods and compositions JINA PHARMACEUTICALS, INC. (US) 2017-05-02 US claimed
EP-2088865-B1 GUGGULPHOSPHOLIPID METHODS AND COMPOSITIONS JINA PHARMACEUTICALS INC (US) 2015-10-21 EP claimed
US-20100151002-A1 Guggulphospholipid Methods and Compositions JINA PHARMACEUTICALS, INC. (US) 2010-06-17 US claimed
EP-2088865-A2 GUGGULPHOSPHOLIPID METHODS AND COMPOSITIONS Jina Pharmaceuticals Inc. (US) 2009-08-19 EP claimed
WO-2008058156-A9 GUGGULPHOSPHOLIPID METHODS AND COMPOSITIONS JINA PHARMACEUTICALS INC (US) 2008-12-04 WO claimed
WO-2008058156-A2 GUGGULPHOSPHOLIPID METHODS AND COMPOSITIONS JINA PHARMACEUTICALS INC. (US) 2008-05-15 WO claimed
EP-0295262-B1 PHENOLIC RESIN-POLYISOCYANATE BINDER SYSTEMS CONTAINING AN ORGANOHALOPHOSPHATE AND USE THEREOF ASHLAND OIL INC (US) 1994-09-07 EP claimed
US-4683252-A Phenolic resin-polyisocyanate binder systems containing an organohalophosphate and use thereof ASHLAND OIL, INC. (US) 1987-07-28 US claimed
CN-122080069-A Phospholipid compounds and uses thereof 2026-05-26 CN disclosed
US-20260015372-A1 Organophosphorous Compounds and Uses Thereof JAL THERAPEUTICS LLC (US) 2026-01-15 US disclosed
US-12473314-B2 Phospholipid compounds and uses thereof GILEAD SCIENCES, INC. (US) 2025-11-18 US disclosed
US-12454540-B2 Prodrugs of L-BHDU and methods of treating viral infections UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (US) 2025-10-28 US disclosed
EP-4537828-A2 PHOSPHOLIPID COMPOUNDS AND USES THEREOF Gilead Sciences, Inc. (US) 2025-04-16 EP disclosed
US-3983064-A Solid, rapid-setting, rigid polyurethanes THE DOW CHEMICAL COMPANY (US) 1976-09-28 US disclosed
US-3983065-A Solid, rapid-setting, rigid polyurethanes THE DOW CHEMICAL COMPANY (US) 1976-09-28 US disclosed
US-3966662-A Solid, rapid-setting, rigid polyurethanes THE DOW CHEMICAL COMPANY (US) 1976-06-29 US disclosed
US-3966664-A Solid, rapid-setting, rigid polyurethanes THE DOW CHEMICAL COMPANY (US) 1976-06-29 US disclosed
US-3965073-A Preparation of rapid setting non-elastomeric polyurethane compositions in the presence of ester-modified polyoxyalkylene compounds THE DOW CHEMICAL COMPANY (US) 1976-06-22 US disclosed
US-3956221-A Rapid setting non-elastomeric polyurethane compositions containing a non-hydroxyl containing ester-modified polyoxylkylene compound THE DOW CHEMICAL COMPANY (US) 1976-05-11 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100151002-A1 Guggulphospholipid Methods and Compositions SGMS2, SGMS1, PLA2G5 LMNA 1323/4885SMN1; SMN2 3094/4885MAPK1 4165/4885
US-20170210775-A1 GUGGULPHOSPHOLIPID METHODS AND COMPOSITIONS SGMS1, SGMS2, GGPS1 LMNA 1667/4885SMN1; SMN2 3304/4885MAPK1 4152/4885
US-20260015372-A1 Organophosphorous Compounds and Uses Thereof ACHE, BCHE, MUSK LMNA 2268/4885SMN1; SMN2 415/4885MAPK1 4808/4885
US-12454540-B2 Prodrugs of L-BHDU and methods of treating viral infections ALKBH3, OGA, ALKBH1 LMNA 2746/4885SMN1; SMN2 3569/4885MAPK1 2678/4885
US-12473314-B2 Phospholipid compounds and uses thereof PHOSPHO1, SGMS2, SGMS1 LMNA 1033/4885SMN1; SMN2 2020/4885MAPK1 4234/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.