SCHEMBL1379792

SCHEMBL1379792

O=C(Nc1ccccn1)c1cccs1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.69
TSHR P16473 1/20 0.68
NPC1 O15118 10/20 0.65
RAB9A P51151 9/20 0.65
SMN1; SMN2 Q16637 5/20 0.65
PKM P14618 2/20 0.65
MITF O75030 1/20 0.64
KMT2A Q03164 4/20 0.60
KDM4E B2RXH2 1/20 0.59
ESR1 P03372 1/20 0.58
POLB P06746 1/20 0.58
STAT3 P40763 1/20 0.58
ESR2 Q92731 1/20 0.58
MEN1 O00255 2/20 0.58
TDP1 Q9NUW8 1/20 0.57
GAA P10253 1/20 0.55
GAPDH P04406 1/20 0.55
HTT P42858 1/20 0.55
GRM4 Q14833 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16011604 0.81 ALDH1A1 (1.00) ALDH1A1TSHRNPC1RAB9ASMN1; SMN2
SCHEMBL16899277 0.81 NPC1 (0.79) ALDH1A1TSHRNPC1RAB9ASMN1; SMN2
SCHEMBL27711484 0.81 TSHR (1.00) ALDH1A1TSHRNPC1RAB9ASMN1; SMN2
SCHEMBL28470273 0.81 NPC1 (0.55) ALDH1A1TSHRNPC1RAB9ASMN1; SMN2
SCHEMBL2438512 0.78 NPC1 (0.57) TSHRNPC1RAB9ASMN1; SMN2PKM
SCHEMBL1844028 0.77 NPC1 (0.60) NPC1RAB9ASMN1; SMN2PKMMITF
SCHEMBL23965986 0.77 L3MBTL1 (0.68) ALDH1A1TSHRNPC1RAB9ASMN1; SMN2
SCHEMBL3407320 0.77 RAB9A (0.76) ALDH1A1TSHRNPC1RAB9ASMN1; SMN2
SCHEMBL30354808 0.77 MEN1 (0.65) ALDH1A1TSHRNPC1RAB9ASMN1; SMN2
SCHEMBL25383237 0.77 MEN1 (0.65) ALDH1A1TSHRNPC1RAB9ASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10464929-B2 Organic molecules for terahertz tagging applications COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) 2019-11-05 US claimed
EP-3094621-A1 ORGANIC MOLECULES FOR TERAHERTZ TAGGING APPLICATIONS Council of Scientific & Industrial Research (IN) 2016-11-23 EP claimed
US-20160335827-A1 ORGANIC MOLECULES FOR TERAHERTZ TAGGING APPLICATIONS COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) 2016-11-17 US claimed
WO-2015104722-A1 ORGANIC MOLECULES FOR TERAHERTZ TAGGING APPLICATIONS COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) 2015-07-16 WO claimed
JP-4828407-B2 2011-11-30 JP claimed
EP-1594869-A2 3-SUBSTITUTED-2(ARYLALKYL)-1-AZABICYCLOALKANES AND METHODS OF USE THEREOF Targacept, Inc. (US) 2005-11-16 EP claimed
WO-2004076449-A2 3-SUBSTITUTED-2(ARYLALKYL)-1-AZABICYCLOALKANES AND METHODS OF USE THEREOF TARGACEPT, INC. (US) 2004-09-10 WO claimed
WO-2025151311-A1 NICOTINAMIDE DERIVATIVES BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 2025-07-17 WO disclosed
CN-109053558-B Synthesis method of N-heterocyclic amide derivative 贵州大学 2022-02-18 CN disclosed
CN-113735850-A Synthesis method of 1,2, 4-triazole compound 河南师范大学 2021-12-03 CN disclosed
EP-3392240-B1 USE OF N-(PYRIDIN-2-YL)-AMIDE AND PHENYL-UREA DERIVATIVES FOR TERAHERTZ TAGGING APPLICATIONS COUNCIL SCIENT IND RES (IN) 2020-06-03 EP disclosed
EP-3392240-B1 USE OF N-(PYRIDIN-2-YL)-AMIDE AND PHENYL-UREA DERIVATIVES FOR TERAHERTZ TAGGING APPLICATIONS COUNCIL SCIENT IND RES (IN) 2020-06-03 EP disclosed
US-10464929-B2 Organic molecules for terahertz tagging applications COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) 2019-11-05 US disclosed
US-8106051-B2 4-Chloro-N-(4-tolyl)benzamide; to enhance the serum level of apoAI SHIONOGI & CO., LTD. (JP) 2012-01-31 US disclosed
US-7429593-B2 Utilities of amide compounds SHIONOGI & CO., LTD. (JP) 2008-09-30 US disclosed
US-7429593-B2 Utilities of amide compounds SHIONOGI & CO., LTD. (JP) 2008-09-30 US disclosed
US-20080221112-A1 4-Chloro-N-(4-tolyl)benzamide; to enhance the serum level of apoAI YAMAMORI TERUO 2008-09-11 US disclosed
US-20080221112-A1 4-Chloro-N-(4-tolyl)benzamide; to enhance the serum level of apoAI YAMAMORI TERUO 2008-09-11 US disclosed
EP-1453828-A2 AZABICYCLIC COMPOUNDS FOR THE TREATMENT OF FIBROMYALGIA SYNDROME AstraZeneca AB (SE) 2004-09-08 EP disclosed
WO-2003032897-A2 AZABICYCLIC COMPOUNDS FOR THE TREATMENT OF FIBROMYALGIA SYNDROME ASTRAZENECA AB (SE) 2003-04-24 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160335827-A1 ORGANIC MOLECULES FOR TERAHERTZ TAGGING APPLICATIONS WIZ, CRYZ, NAA15 ALDH1A1 978/4885TSHR 2793/4885NPC1 4342/4885
US-20080221112-A1 4-Chloro-N-(4-tolyl)benzamide; to enhance the serum level of apoAI APOL1, PON1, APOB ALDH1A1 1284/4885TSHR 2036/4885NPC1 226/4885
US-10464929-B2 Organic molecules for terahertz tagging applications WIZ, CRYZ, NAA15 ALDH1A1 978/4885TSHR 2793/4885NPC1 4342/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.