Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
| ▸ | RORA | P35398 | 6/20 | 0.49 |
| ▸ | RORC | P51449 | 6/20 | 0.49 |
| ▸ | RORB | Q92753 | 6/20 | 0.49 |
| ▸ | PGR | P06401 | 5/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | FAAH | O00519 | 1/20 | 0.43 |
| ▸ | MGLL | Q99685 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29366177 | 0.95 | TDP1 (0.51) | TDP1L3MBTL1RORARORCRORB | |
| SCHEMBL559250 | 0.95 | TDP1 (0.51) | TDP1L3MBTL1RORARORCRORB | |
| SCHEMBL10154408 | 0.86 | CASP3 (0.43) | TDP1L3MBTL1SMN1; SMN2ALDH1A1POLB | |
| SCHEMBL13799553 | 0.86 | MPO (0.47) | TDP1L3MBTL1ALDH1A1LMNA | |
| SCHEMBL4600442 | 0.86 | ALDH1A1 (0.60) | TDP1L3MBTL1ALDH1A1KDM4EHPGD | |
| SCHEMBL409641 | 0.85 | TDP1 (0.45) | TDP1L3MBTL1SMN1; SMN2FAAHMGLL | |
| SCHEMBL14306505 | 0.84 | GPR3 (0.39) | TDP1L3MBTL1SMN1; SMN2ALDH1A1POLB | |
| SCHEMBL13799552 | 0.83 | MPO (0.45) | TDP1L3MBTL1SMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL24270358 | 0.83 | FABP4 (0.49) | TDP1L3MBTL1ALDH1A1KDM4EHPGD | |
| SCHEMBL24270357 | 0.82 | MAPT (0.40) | TDP1L3MBTL1RORARORCRORB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7541463-B2 | Sulfur-containing naphthalimide derivatives | EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY (CN) | 2009-06-02 | — | — | US | disclosed |
| US-7541463-B2 | Sulfur-containing naphthalimide derivatives | EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY (CN) | 2009-06-02 | — | — | US | disclosed |
| US-20080234287-A1 | SULFUR-CONTAINING NAPHTHALIMIDE DERIVATIVES | QIAN XUHONG | 2008-09-25 | — | — | US | disclosed |
| US-20080234287-A1 | SULFUR-CONTAINING NAPHTHALIMIDE DERIVATIVES | QIAN XUHONG | 2008-09-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080234287-A1 | SULFUR-CONTAINING NAPHTHALIMIDE DERIVATIVES | HCCS, SQOR, MKI67 | TDP1 4749/4885L3MBTL1 509/4885RORA 1506/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.