Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPO | P05164 | 5/20 | 0.45 |
| ▸ | HAVCR2 | Q8TDQ0 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.42 |
| ▸ | TERT | O14746 | 1/20 | 0.42 |
| ▸ | TOP2A | P11388 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | RAD52 | P43351 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | XDH | P47989 | 2/20 | 0.38 |
| ▸ | HTR6 | P50406 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | RXRA | P19793 | 1/20 | 0.38 |
| ▸ | STAT3 | P40763 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13799553 | 0.93 | MPO (0.47) | MPOTDP1TOP2ARAD52MEN1 | |
| SCHEMBL13799551 | 0.83 | TDP1 (0.57) | TDP1KDM4ESMN1; SMN2ALDH1A1L3MBTL1 | |
| SCHEMBL14306505 | 0.83 | GPR3 (0.39) | TDP1SMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL10154408 | 0.82 | CASP3 (0.43) | TDP1SMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL29366177 | 0.81 | TDP1 (0.51) | TDP1KDM4ESMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL559250 | 0.81 | TDP1 (0.51) | TDP1KDM4ESMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL11974069 | 0.81 | GPR3 (0.45) | TDP1KDM4ESMN1; SMN2MEN1KMT2A | |
| SCHEMBL4600442 | 0.80 | ALDH1A1 (0.60) | TDP1KDM4EMEN1KMT2AALDH1A1 | |
| SCHEMBL30782383 | 0.80 | CYP2D6 (0.47) | MPOTDP1TOP2ARAD52ALDH1A1 | |
| SCHEMBL13589109 | 0.79 | L3MBTL1 (0.36) | TDP1KDM4ESMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7541463-B2 | Sulfur-containing naphthalimide derivatives | EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY (CN) | 2009-06-02 | — | — | US | disclosed |
| US-7541463-B2 | Sulfur-containing naphthalimide derivatives | EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY (CN) | 2009-06-02 | — | — | US | disclosed |
| US-20080234287-A1 | SULFUR-CONTAINING NAPHTHALIMIDE DERIVATIVES | QIAN XUHONG | 2008-09-25 | — | — | US | disclosed |
| US-20080234287-A1 | SULFUR-CONTAINING NAPHTHALIMIDE DERIVATIVES | QIAN XUHONG | 2008-09-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080234287-A1 | SULFUR-CONTAINING NAPHTHALIMIDE DERIVATIVES | HCCS, SQOR, MKI67 | MPO 1320/4885HAVCR2 1444/4885TDP1 4749/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.