Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.36 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.36 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.36 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.35 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17320139 | 0.86 | ACHE (0.39) | NPC1RAB9ASMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL17320137 | 0.85 | BAZ2B (0.42) | RAB9ASMN1; SMN2ALDH1A1LMNAHTT | |
| SCHEMBL2476989 | 0.84 | ABCB11 (0.46) | NPC1RAB9ASMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL8959923 | 0.84 | KDM4E (0.37) | NPC1RAB9AALDH1A1MTNR1ATSHR | |
| SCHEMBL22415249 | 0.84 | MTNR1A (0.36) | NPC1RAB9AALDH1A1HTTMTNR1A | |
| SCHEMBL29507033 | 0.84 | LMNA (0.40) | RAB9AALDH1A1LMNAHTTMTNR1A | |
| SCHEMBL2470098 | 0.84 | LMNA (0.40) | RAB9AALDH1A1LMNAHTTMTNR1A | |
| SCHEMBL13172044 | 0.82 | MTNR1A (0.55) | RAB9AALDH1A1LMNAHTTMTNR1A | |
| SCHEMBL1051164 | 0.80 | CREBBP (0.50) | NPC1RAB9ASMN1; SMN2ALDH1A1HTT | |
| SCHEMBL29386752 | 0.80 | CREBBP (0.50) | NPC1RAB9ASMN1; SMN2ALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2531488-B1 | INDIRUBIN-3'-OXIME DERIVATIVES AS POTENT CYCLIN DEPENDENT KINASE INHIBITORS | ANYGEN CO LTD (KR) | 2015-12-09 | — | — | EP | disclosed |
| EP-2531488-B1 | INDIRUBIN-3'-OXIME DERIVATIVES AS POTENT CYCLIN DEPENDENT KINASE INHIBITORS | ANYGEN CO LTD (KR) | 2015-12-09 | — | — | EP | disclosed |
| US-8859783-B2 | Indirubin-3′-oxime derivatives as potent cyclin dependent kinase inhibitors | ANYGEN CO., LTD. (KR) | 2014-10-14 | — | — | US | disclosed |
| US-8859783-B2 | Indirubin-3′-oxime derivatives as potent cyclin dependent kinase inhibitors | ANYGEN CO., LTD. (KR) | 2014-10-14 | — | — | US | disclosed |
| US-20120295948-A1 | INDIRUBIN-3'-OXIME DERIVATIVES AS POTENT CYCLIN DEPENDENT KINASE INHIBITORS | ANYGEN CO., LTD. (KR) | 2012-11-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120295948-A1 | INDIRUBIN-3'-OXIME DERIVATIVES AS POTENT CYCLIN DEPENDENT KINASE INHIBITORS | CCNI, CCNK, CDK2 | NPC1 4067/4885RAB9A 4312/4885SMN1; SMN2 2534/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.