Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SSTR3 | P32745 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16978964 | 0.91 | SMN1; SMN2 (0.34) | SSTR3SMN1; SMN2HSD17B10 | |
| SCHEMBL25825627 | 0.78 | TSHR (0.36) | SMN1; SMN2 | |
| SCHEMBL15315437 | 0.77 | HTR1A (0.39) | SMN1; SMN2HSD17B10 | |
| SCHEMBL21799915 | 0.77 | ANPEP (0.42) | — | |
| SCHEMBL15315438 | 0.77 | ANPEP (0.42) | — | |
| SCHEMBL2745491 | 0.75 | ALDH1A1 (0.32) | HSD17B10 | |
| SCHEMBL145249 | 0.75 | ALDH1A1 (0.32) | HSD17B10 | |
| SCHEMBL145251 | 0.75 | ALDH1A1 (0.32) | HSD17B10 | |
| SCHEMBL30327955 | 0.75 | ALDH1A1 (0.32) | HSD17B10 | |
| SCHEMBL113491 | 0.75 | ALDH1A1 (0.32) | HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090093452-A1 | Pyrrole, Thiophene, Furan, Imidazole, Oxazole, and Thiazole Derivatives | PFIZER INC. | 2009-04-09 | — | — | US | disclosed |
| US-20090093452-A1 | Pyrrole, Thiophene, Furan, Imidazole, Oxazole, and Thiazole Derivatives | PFIZER INC. | 2009-04-09 | — | — | US | disclosed |
| US-20080119457-A1 | Benzene, Pyridine, and Pyridazine Derivatives | SERENEX, INC. | 2008-05-22 | — | — | US | disclosed |
| US-20080119457-A1 | Benzene, Pyridine, and Pyridazine Derivatives | SERENEX, INC. | 2008-05-22 | — | — | US | disclosed |
| US-20080076813-A1 | Benzene, Pyridine, and Pyridazine Derivatives | SERENEX, INC. | 2008-03-27 | — | — | US | disclosed |
| US-20080076800-A1 | Benzene, Pyridine, and Pyridazine Derivatives | SERENEX, INC. | 2008-03-27 | — | — | US | disclosed |
| US-20080076813-A1 | Benzene, Pyridine, and Pyridazine Derivatives | SERENEX, INC. | 2008-03-27 | — | — | US | disclosed |
| US-20080076800-A1 | Benzene, Pyridine, and Pyridazine Derivatives | SERENEX, INC. | 2008-03-27 | — | — | US | disclosed |
| US-20080070918-A1 | Dihydropyridazine, Tetrahydropyridine, Chromanone, and Dihydronaphthalenone Derivatives | SERENEX, INC. | 2008-03-20 | — | — | US | disclosed |
| US-20080070918-A1 | Dihydropyridazine, Tetrahydropyridine, Chromanone, and Dihydronaphthalenone Derivatives | SERENEX, INC. | 2008-03-20 | — | — | US | disclosed |
| US-20080070930-A1 | Pyrimidine and Pyrazine Derivatives | SERENEX, INC. | 2008-03-20 | — | — | US | disclosed |
| US-20080070930-A1 | Pyrimidine and Pyrazine Derivatives | SERENEX, INC. | 2008-03-20 | — | — | US | disclosed |
| WO-2008024980-A2 | PYRROLE, THIOPHENE, FURAN, IMIDAZOLE, OXAZOLE, AND THIAZOLE DERIVATIVES | SERENEX, INC. (US) | 2008-02-28 | — | — | WO | disclosed |
| WO-2008024970-A2 | TETRAHYDROINDOLONE AND TETRAHYDROINDAZOLONE DERIVATIVES | SERENEX, INC. (US) | 2008-02-28 | — | — | WO | disclosed |
| WO-2008024978-A2 | TETRAHYDROINDOLONE AND TETRAHYDROINDAZOLONE DERIVATIVES | SERENEX, INC. (US) | 2008-02-28 | — | — | WO | disclosed |
| WO-2008024963-A1 | BENZENE, PYRIDINE, AND PYRIDAZINE DERIVATIVES | SERENEX, INC. (US) | 2008-02-28 | — | — | WO | disclosed |
| WO-2008024961-A1 | DIHYDROPYRIDAZINE, TETRAHYDROPYRIDINE, CHROMANONE, AND DIHYDRONAPHTHALENONE DERIVATIVES AS HEAT-SHOCK PROTEIN 90 INHIBITORS | SERENEX, INC. (US) | 2008-02-28 | — | — | WO | disclosed |
| WO-2008024974-A1 | PYRIMIDINE AND PYRAZINE DERIVATIVES | SERENEX, INC. (US) | 2008-02-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080070930-A1 | Pyrimidine and Pyrazine Derivatives | P2RX7, P2RX5, P2RX3 | SSTR3 732/4885SMN1; SMN2 3098/4885HSD17B10 4160/4885 |
| US-20080070918-A1 | Dihydropyridazine, Tetrahydropyridine, Chromanone, and Dihydronaphthalenone Derivatives | QDPR, CCND2, CCND1 | SSTR3 3115/4885SMN1; SMN2 4029/4885HSD17B10 355/4885 |
| US-20080076800-A1 | Benzene, Pyridine, and Pyridazine Derivatives | RB1, MKI67, CCNB1 | SSTR3 2178/4885SMN1; SMN2 3893/4885HSD17B10 3768/4885 |
| US-20080076813-A1 | Benzene, Pyridine, and Pyridazine Derivatives | MKI67, CCNB1, CCNB3 | SSTR3 2234/4885SMN1; SMN2 3593/4885HSD17B10 3184/4885 |
| US-20080119457-A1 | Benzene, Pyridine, and Pyridazine Derivatives | MKI67, CCNB1, RB1 | SSTR3 3249/4885SMN1; SMN2 2840/4885HSD17B10 3567/4885 |
| US-20090093452-A1 | Pyrrole, Thiophene, Furan, Imidazole, Oxazole, and Thiazole Derivatives | JAK3, JAK2, FLT4 | SSTR3 324/4885SMN1; SMN2 3904/4885HSD17B10 3627/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.