Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | KIF11 | P52732 | 1/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9543849 | 0.85 | KIF11 (0.44) | MAPTHSD11B1KIF11 | |
| SCHEMBL11799039 | 0.80 | AKR1C1 (0.40) | GAAMAPTHDAC9SIGMAR1AKR1C1 | |
| SCHEMBL6071126 | 0.75 | GAA (0.40) | GAAMAPTLMNABLMSMN1; SMN2 | |
| SCHEMBL9527735 | 0.75 | LMNA (0.42) | GAAMAPTSIGMAR1LMNABLM | |
| SCHEMBL7617882 | 0.73 | SIGMAR1 (0.45) | SIGMAR1 | |
| SCHEMBL7782470 | 0.71 | KDM1A (0.43) | SIGMAR1 | |
| SCHEMBL17273470 | 0.71 | SIGMAR1 (0.38) | GAAMAPTHDAC9SIGMAR1AKR1C1 | |
| SCHEMBL8410307 | 0.71 | HDAC9 (0.44) | GAAMAPTHDAC9HDAC4 | |
| SCHEMBL8409829 | 0.70 | MAOB (0.40) | GAAMAPTHDAC9LMNABLM | |
| SCHEMBL3800430 | 0.70 | GAA (0.36) | GAAMAPTSIGMAR1LMNABLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-H08510211-A | — | — | 1996-10-29 | — | — | JP | claimed |
| EP-0699069-A4 | — | — | 1996-04-03 | — | — | EP | claimed |
| EP-0699069-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1996-03-06 | — | — | EP | claimed |
| WO-1994025013-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1994-11-10 | — | — | WO | claimed |