Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 5/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 6/20 | 0.33 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.33 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.33 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.33 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.33 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.32 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.31 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.31 |
| ▸ | BRD2 | P25440 | 1/20 | 0.31 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.31 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26051138 | 0.74 | MAPK14 (0.56) | BRD4MAPK14MEN1MAPTHPGD | |
| SCHEMBL13924849 | 0.67 | SLC6A4 (0.46) | MAPK8 | |
| SCHEMBL2441454 | 0.66 | MAPK14 (0.58) | BRD4MAPK14MAPK11MAPK8MAPK9 | |
| SCHEMBL14838623 | 0.64 | PKM (0.44) | MEN1MAPTKMT2A | |
| SCHEMBL20155404 | 0.61 | TRPA1 (0.40) | BRD4 | |
| SCHEMBL1149524 | 0.61 | HSPB1 (0.59) | PTGS2MAPK14EPAS1 | |
| SCHEMBL10456772 | 0.60 | TRPA1 (0.56) | EPAS1 | |
| SCHEMBL1127669 | 0.60 | KDM4E (0.59) | KMT2A | |
| SCHEMBL24314192 | 0.59 | TRPV4 (0.50) | MEN1MAPTKMT2A | |
| SCHEMBL1149522 | 0.59 | HSPB1 (0.53) | MAPK14EPAS1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3111937-A1 | MEDICAMENT FOR TREATMENT OF LIVER CANCER | Helmholtz-Zentrum für Infektionsforschung GmbH (DE) | 2017-01-04 | — | — | EP | disclosed |