Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 1/20 | 0.56 |
| ▸ | FKBP1A | P62942 | 7/20 | 0.56 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.55 |
| ▸ | CMA1 | P23946 | 5/20 | 0.53 |
| ▸ | ACE | P12821 | 1/20 | 0.52 |
| ▸ | PREP | P48147 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3470867 | 1.00 | CTSL (0.56) | CTSLFKBP1AKLK5CMA1ACE | |
| SCHEMBL8133863 | 1.00 | CTSL (0.56) | CTSLFKBP1AKLK5CMA1ACE | |
| SCHEMBL12023625 | 0.92 | ALDH1A1 (0.53) | CTSLFKBP1AKLK5CMA1ACE | |
| SCHEMBL478151 | 0.92 | ALDH1A1 (0.53) | CTSLFKBP1AKLK5CMA1ACE | |
| SCHEMBL19198454 | 0.91 | FKBP1A (0.54) | CTSLFKBP1AKLK5CMA1ACE | |
| SCHEMBL10882017 | 0.90 | PREP (0.61) | CTSLFKBP1AKLK5CMA1ACE | |
| SCHEMBL7265704 | 0.90 | PREP (0.61) | CTSLFKBP1AKLK5CMA1ACE | |
| SCHEMBL9699149 | 0.90 | PREP (0.61) | CTSLFKBP1AKLK5CMA1ACE | |
| SCHEMBL28545846 | 0.90 | PREP (0.61) | CTSLFKBP1AKLK5CMA1ACE | |
| SCHEMBL24837864 | 0.90 | FKBP1A (0.55) | FKBP1AALDH1A1CYP3A4TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090048226-A1 | Inhibitors of caspases | VERTEX PHARMACEUTICALS INCORPORATED | 2009-02-19 | — | — | US | disclosed |
| US-7358273-B2 | Inhibitors of caspases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-04-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090048226-A1 | Inhibitors of caspases | CASP1, APAF1, IRF3 | CTSL 89/4885FKBP1A 512/4885KLK5 2074/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.